1-(1-(3-aminobenzo[d]isoxazol-5-yl)-3-tert-butyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea

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Chemical Name:1-(1-(3-aminobenzo[d]isoxazol-5-yl)-3-tert-butyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea
CAS No.:1020172-74-0
Molecular Formula:C₂₈H₂₇FN₈O₄
Molecular Weight:558.572
Hs Code.:

Synonyms:1-(1-(3-aminobenzo[d]isoxazol-5-yl)-3-tert-butyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea

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Chemical Property of 1-(1-(3-aminobenzo[d]isoxazol-5-yl)-3-tert-butyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea

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Technology Process of 1-(1-(3-aminobenzo[d]isoxazol-5-yl)-3-tert-butyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea

There total 9 articles about 1-(1-(3-aminobenzo[d]isoxazol-5-yl)-3-tert-butyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 1020174-00-8
C₃₁H₃₁FN₈O₄

: 1020172-74-0
1-(1-(3-aminobenzo[d]isoxazol-5-yl)-3-tert-butyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea

Guidance literature:: C₃₁H₃₁FN₈O₄; With hydrogenchloride; In ethanol; water; for 96h;

With sodium carbonate; In water;

Reference yield:

: 757251-39-1
4-(4-amino-3-fluorophenoxy)pyridine-2-carboxylic acid methyl amide

: 1020173-99-2
C₂₁H₂₅N₅O₃

: 1020172-74-0
1-(1-(3-aminobenzo[d]isoxazol-5-yl)-3-tert-butyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1: 1-Methylpyrrolidine / tetrahydrofuran / 55 °C

2: hydrogenchloride / water / 96 h

With 1-Methylpyrrolidine; hydrogenchloride; In tetrahydrofuran; water;

Reference yield:

: 59997-51-2
trimethylacetylacetonitrile

: 1020172-74-0
1-(1-(3-aminobenzo[d]isoxazol-5-yl)-3-tert-butyl-1H-pyrazol-5-yl)-3-(2-fluoro-4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenyl)urea

Guidance literature:: Multi-step reaction with 5 steps

1.1: tin(II) chloride dihdyrate; sodium nitrite; hydrogenchloride / water / 3.5 h / 0 °C

1.2: 28 h / Reflux

2.1: potassium tert-butylate / N,N-dimethyl acetamide / 0.75 h / 20 °C

3.1: sodium carbonate / ethyl acetate; water / 4 h / 20 °C

4.1: 1-Methylpyrrolidine / tetrahydrofuran / 55 °C

5.1: hydrogenchloride / water / 96 h

With 1-Methylpyrrolidine; hydrogenchloride; tin(II) chloride dihdyrate; potassium tert-butylate; sodium carbonate; sodium nitrite; In tetrahydrofuran; N,N-dimethyl acetamide; water; ethyl acetate;