2-(4-(5-phenyl-2H-tetrazol-2-yl)butyl)isoindoline-1,3-dione

Base Information

• Chemical Name: 2-(4-(5-phenyl-2H-tetrazol-2-yl)butyl)isoindoline-1,3-dione
• CAS No.: 937878-30-3
• Molecular Formula: C₁₉H₁₇N₅O₂
• Molecular Weight: 347.376
• Mol file: 937878-30-3.mol

Synonyms:2-(4-(5-phenyl-2H-tetrazol-2-yl)butyl)isoindoline-1,3-dione

Chemical Property of 2-(4-(5-phenyl-2H-tetrazol-2-yl)butyl)isoindoline-1,3-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-(5-phenyl-2H-tetrazol-2-yl)butyl)isoindoline-1,3-dione

There total 1 articles about 2-(4-(5-phenyl-2H-tetrazol-2-yl)butyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(4-bromobutyl)isoindoline-1,3-dione (5394-18-3) + 5-phenyl-2H-1,2,3,4-tetrazole (18039-42-4) → 2-(4-(5-phenyl-2H-tetrazol-2-yl)butyl)isoindoline-1,3-dione (937878-30-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃; for 10h; Inert atmosphere;

DOI:10.1038/ja.2011.50

Reference yield: 87.0%

2-(4-(5-phenyl-2H-tetrazol-2-yl)butyl)isoindoline-1,3-dione (937878-30-3) → 4-(5-phenyl-2H-tetrazol-2-yl)butan-1-amine (1240470-76-1)

Guidance literature:

With hydrazine hydrate; In ethanol; water; acetonitrile; for 6h; Reflux;

DOI:10.1038/ja.2011.50

Reference yield:

2-(4-(5-phenyl-2H-tetrazol-2-yl)butyl)isoindoline-1,3-dione (937878-30-3) → C42H64N6O10

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol; water; acetonitrile / 6 h / Reflux

2: acetonitrile / 24 h / Heating

3: methanol / 25 h / 60 °C

With methanol; hydrazine hydrate; In ethanol; water; acetonitrile;

DOI:10.1038/ja.2011.50

upstream raw materials:

2-(4-bromobutyl)isoindoline-1,3-dione

5-phenyl-2H-1,2,3,4-tetrazole

Downstream raw materials:

4-(5-phenyl-2H-tetrazol-2-yl)butan-1-amine