N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-2-diethylphosphonoacetamide

Base Information

Chemical Name:N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-2-diethylphosphonoacetamide
CAS No.:1269662-82-9
Molecular Formula:C₂₆H₂₇ClN₅O₅P
Molecular Weight:555.958
Hs Code.:

Synonyms:N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-2-diethylphosphonoacetamide

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Chemical Property of N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-2-diethylphosphonoacetamide

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Technology Process of N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-2-diethylphosphonoacetamide

There total 4 articles about N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-2-diethylphosphonoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.7%

: 179688-74-5
N⁴-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)quinazoline-4,6-diamine

: 3095-95-2
diethylphosphonoacetic acid

: 1269662-82-9
N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-2-diethylphosphonoacetamide

Guidance literature:: diethylphosphonoacetic acid; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 20 ℃; for 2h; Cooling with ice;

N⁴-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)quinazoline-4,6-diamine; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1h; Cooling with ice;

Reference yield:

: 19815-16-8
4-chloro-6-nitro-quinazoline

: 1269662-82-9
N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-2-diethylphosphonoacetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: isopropyl alcohol / 5 h / Reflux

2.1: hydrogenchloride; iron / ethanol; water / 2 h / Reflux

2.2: pH > 7

3.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C / Cooling with ice

3.2: 1 h / 20 °C / Cooling with ice

With hydrogenchloride; oxalyl dichloride; iron; N,N-dimethyl-formamide; In ethanol; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 179688-70-1
N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-6-nitroquinazolin-4-amine

: 1269662-82-9
N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-2-diethylphosphonoacetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; iron / ethanol; water / 2 h / Reflux

1.2: pH > 7

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C / Cooling with ice

2.2: 1 h / 20 °C / Cooling with ice

With hydrogenchloride; oxalyl dichloride; iron; N,N-dimethyl-formamide; In ethanol; dichloromethane; water;