(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-3-[(2S)-1-methylpyrrolidin-2-yl]propan-2-enoylamine

Base Information

Chemical Name:(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-3-[(2S)-1-methylpyrrolidin-2-yl]propan-2-enoylamine
CAS No.:1269662-72-7
Molecular Formula:C₂₈H₂₇ClN₆O₂
Molecular Weight:515.014
Hs Code.:

Synonyms:(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-3-[(2S)-1-methylpyrrolidin-2-yl]propan-2-enoylamine

Suppliers and Price of (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-3-[(2S)-1-methylpyrrolidin-2-yl]propan-2-enoylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-3-[(2S)-1-methylpyrrolidin-2-yl]propan-2-enoylamine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-3-[(2S)-1-methylpyrrolidin-2-yl]propan-2-enoylamine

There total 6 articles about (E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-3-[(2S)-1-methylpyrrolidin-2-yl]propan-2-enoylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 1269662-82-9
N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-2-diethylphosphonoacetamide

: 852324-29-9
(S)-N-methylpyrrolidine-2-carboxaldehyde

: 1269662-72-7
(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-3-[(2S)-1-methylpyrrolidin-2-yl]propan-2-enoylamine

Guidance literature:: N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-2-diethylphosphonoacetamide; With lithium hexamethyldisilazane; In tetrahydrofuran; toluene; for 0.75h; Cooling with dry ice;

(S)-N-methylpyrrolidine-2-carboxaldehyde; In tetrahydrofuran; toluene; at 20 ℃; for 13h; Cooling with dry ice;

Reference yield:

: 179688-70-1
N-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)-6-nitroquinazolin-4-amine

: 1269662-72-7
(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-3-[(2S)-1-methylpyrrolidin-2-yl]propan-2-enoylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride; iron / ethanol; water / 2 h / Reflux

1.2: pH > 7

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C / Cooling with ice

2.2: 1 h / 20 °C / Cooling with ice

3.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 0.75 h / Cooling with dry ice

3.2: 13 h / 20 °C / Cooling with dry ice

With hydrogenchloride; oxalyl dichloride; iron; N,N-dimethyl-formamide; lithium hexamethyldisilazane; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;

Reference yield:

: 179688-74-5
N⁴-(3-chloro-4-(pyridin-2-ylmethoxy)phenyl)quinazoline-4,6-diamine

: 1269662-72-7
(E)-N-[4-[[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]amino]quinazolin-6-yl]-3-[(2S)-1-methylpyrrolidin-2-yl]propan-2-enoylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C / Cooling with ice

1.2: 1 h / 20 °C / Cooling with ice

2.1: lithium hexamethyldisilazane / toluene; tetrahydrofuran / 0.75 h / Cooling with dry ice

2.2: 13 h / 20 °C / Cooling with dry ice

With oxalyl dichloride; N,N-dimethyl-formamide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; toluene;