2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide hydrochloride

Base Information

Chemical Name:2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide hydrochloride
CAS No.:1606974-16-6
Molecular Formula:C₂₅H₂₅ClN₄O₂*ClH
Molecular Weight:485.413
Hs Code.:

Synonyms:2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide hydrochloride

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Chemical Property of 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide hydrochloride

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Technology Process of 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide hydrochloride

There total 7 articles about 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1606976-70-8
2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide

: 1606974-16-6
2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide hydrochloride

Guidance literature:: With hydrogenchloride; In methanol;

Reference yield:

: 1606976-64-0
diisopropyl 2-(4-nitrobenzyl)malonate

: 1606974-16-6
2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 21 h / 0 - 20 °C

2.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 22 h / 50 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / 1,4-dioxane; dichloromethane / 4 h / 0 °C

3.2: 15 h / 0 °C

4.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 6 h / 760.05 Torr

5.1: hydrogenchloride / 1,4-dioxane; 1-methyl-pyrrolidin-2-one / 8 h / 150 °C / Microwave irradiation

6.1: hydrogenchloride / methanol

With hydrogenchloride; oxalyl dichloride; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; sodium hydride; N,N-dimethyl-formamide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 2-methyl-2-(4-nitrobenzyl)malonamide

: 1606974-16-6
2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 6 h / 760.05 Torr

2: hydrogenchloride / 1,4-dioxane; 1-methyl-pyrrolidin-2-one / 8 h / 150 °C / Microwave irradiation

3: hydrogenchloride / methanol

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; methanol; ethanol; ethyl acetate;