2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide

Base Information

Chemical Name:2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide
CAS No.:1606976-70-8
Molecular Formula:C₂₅H₂₅ClN₄O₂
Molecular Weight:448.952
Hs Code.:

Synonyms:2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide

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Chemical Property of 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide

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Technology Process of 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide

There total 6 articles about 2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1606976-69-5
2-(4-aminobenzyl)-2-methylmalonamide

: 1606978-25-9
4-chloro-2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridine

: 1606976-70-8
2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; at 150 ℃; for 8h; Microwave irradiation;

Reference yield:

: 100-11-8
1-bromomethyl-4-nitro-benzene

: 1606976-70-8
2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C

1.2: 19 h

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 21 h / 0 - 20 °C

3.1: lithium hydroxide monohydrate; water / 1,4-dioxane / 22 h / 50 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / 1,4-dioxane; dichloromethane / 4 h / 0 °C

4.2: 15 h / 0 °C

5.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 6 h / 760.05 Torr

6.1: hydrogenchloride / 1,4-dioxane; 1-methyl-pyrrolidin-2-one / 8 h / 150 °C / Microwave irradiation

With hydrogenchloride; oxalyl dichloride; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; sodium hydride; N,N-dimethyl-formamide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 144842-69-3
2-methyl-2-(4-nitrobenzyl)malonic acid

: 1606976-70-8
2-(4-((2-(3-chlorophenyl)-6,7-dihydro-5H-cyclopenta[b]pyridin-4-yl)amino)benzyl)-2-methylmalonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / 1,4-dioxane; dichloromethane / 4 h / 0 °C

1.2: 15 h / 0 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 6 h / 760.05 Torr

3.1: hydrogenchloride / 1,4-dioxane; 1-methyl-pyrrolidin-2-one / 8 h / 150 °C / Microwave irradiation

With hydrogenchloride; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; N,N-dimethyl-formamide; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; ethyl acetate;