Furan-2-carboxylic acid (cyano-phenyl-methyl)-amide

Base Information

• Chemical Name: Furan-2-carboxylic acid (cyano-phenyl-methyl)-amide
• CAS No.: 118880-83-4
• Molecular Formula: C₁₃H₁₀N₂O₂
• Molecular Weight: 226.235
• Mol file: 118880-83-4.mol

Synonyms:Furan-2-carboxylic acid (cyano-phenyl-methyl)-amide

Chemical Property of Furan-2-carboxylic acid (cyano-phenyl-methyl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Furan-2-carboxylic acid (cyano-phenyl-methyl)-amide

There total 1 articles about Furan-2-carboxylic acid (cyano-phenyl-methyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-furanoic acid (88-14-2) + 2-amino-2-phenylacetonitrile (16750-42-8,41804-94-8) → Furan-2-carboxylic acid (cyano-phenyl-methyl)-amide (118880-83-4)

Guidance literature:

With 1,1'-carbonyldiimidazole; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1021/jm00038a010

Reference yield:

Furan-2-carboxylic acid (cyano-phenyl-methyl)-amide (118880-83-4) → Furan-2-carboxylic acid (2-amino-1-phenyl-ethyl)-amide (1026371-63-0)

Guidance literature:

With ammonia; hydrogen; ranney nickel; In methanol; under 2585.7 Torr; Ambient temperature;

DOI:10.1021/jm00038a010

Reference yield:

Furan-2-carboxylic acid (cyano-phenyl-methyl)-amide (118880-83-4) → (+/-)-N-[2-[[[[2,6-bis(1-methylethyl)phenyl]amino]carbonyl]amino]-1-phenylethyl]-2-furanylamide

Guidance literature:

Multi-step reaction with 2 steps

1: NH₃, H₂ / Ranney nickel / methanol / 2585.7 Torr / Ambient temperature

2: tetrahydrofuran / 2 h / Ambient temperature

With ammonia; hydrogen; ranney nickel; In tetrahydrofuran; methanol;

DOI:10.1021/jm00038a010

upstream raw materials:

2-furanoic acid

2-amino-2-phenylacetonitrile

Downstream raw materials:

Furan-2-carboxylic acid (2-amino-1-phenyl-ethyl)-amide

Refernces