(R)-(3-fluorophenyl)(phenyl)methanol

Base Information

• Chemical Name: (R)-(3-fluorophenyl)(phenyl)methanol
• CAS No.: 662136-54-1
• Molecular Formula: C₁₃H₁₁FO
• Molecular Weight: 202.228
• Mol file: 662136-54-1.mol

Synonyms:(R)-(3-fluorophenyl)(phenyl)methanol

Chemical Property of (R)-(3-fluorophenyl)(phenyl)methanol

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(3-fluorophenyl)(phenyl)methanol

There total 12 articles about (R)-(3-fluorophenyl)(phenyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-Fluorobenzaldehyde (456-48-4) + phenylboronic acid (98-80-6) → (R)-(3-fluorophenyl)(phenyl)methanol (662136-54-1)

Guidance literature:

phenylboronic acid; With diethylzinc; In hexane; toluene; at 60 ℃; for 12h; Inert atmosphere;

With C₂₉H₃₁N₂PS; In hexane; toluene; at 20 ℃; for 0.5h; Inert atmosphere;

3-Fluorobenzaldehyde; In hexane; toluene; at -40 ℃; for 24h; enantioselective reaction; Inert atmosphere;

DOI:10.1016/j.tetasy.2016.11.011

Reference yield: 76.0%

(R)-5-fluoro-1,1-dimethyl-3-phenyl-1,3-dihydrobenzo[c][1,2]oxasilole → (R)-(3-fluorophenyl)(phenyl)methanol (662136-54-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1021/jacs.5b07827

Reference yield: 70.0%

3-fluorobenzophenone (345-69-7) → (R)-(3-fluorophenyl)(phenyl)methanol (662136-54-1)

Guidance literature:

With ketoreductase KmCR₂; NADPH; In aq. phosphate buffer; at 30 ℃; for 24h; pH=7; Enzymatic reaction;

DOI:10.1002/adsc.201801543

upstream raw materials:

3-Fluorobenzaldehyde

phenylboronic acid

phenylmagnesium bromide

2-(dimethyl(phenyl)silyl)-5-fluorobenzaldehyde