(S)-3-[2-(tert-Butoxycarbonyl-ethyl-amino)-acetylamino]-N-((S)-1-carbamoyl-2-cyclohexyl-ethyl)-succinamic acid benzyl ester

Base Information

• Chemical Name: (S)-3-[2-(tert-Butoxycarbonyl-ethyl-amino)-acetylamino]-N-((S)-1-carbamoyl-2-cyclohexyl-ethyl)-succinamic acid benzyl ester
• CAS No.: 204139-57-1
• Molecular Formula: C₂₉H₄₄N₄O₇
• Molecular Weight: 560.691
• Mol file: 204139-57-1.mol

Synonyms:(S)-3-[2-(tert-Butoxycarbonyl-ethyl-amino)-acetylamino]-N-((S)-1-carbamoyl-2-cyclohexyl-ethyl)-succinamic acid benzyl ester

Chemical Property of (S)-3-[2-(tert-Butoxycarbonyl-ethyl-amino)-acetylamino]-N-((S)-1-carbamoyl-2-cyclohexyl-ethyl)-succinamic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-3-[2-(tert-Butoxycarbonyl-ethyl-amino)-acetylamino]-N-((S)-1-carbamoyl-2-cyclohexyl-ethyl)-succinamic acid benzyl ester

There total 5 articles about (S)-3-[2-(tert-Butoxycarbonyl-ethyl-amino)-acetylamino]-N-((S)-1-carbamoyl-2-cyclohexyl-ethyl)-succinamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

BOC-L-aspartic acid 4-benzyl ester (7536-58-5,98482-77-0) → (S)-3-[2-(tert-Butoxycarbonyl-ethyl-amino)-acetylamino]-N-((S)-1-carbamoyl-2-cyclohexyl-ethyl)-succinamic acid benzyl ester (204139-57-1)

Guidance literature:

Multi-step reaction with 4 steps

1: N-methylpiperidine / CH₂Cl₂; toluene / 0.03 h / 0 °C

2: N-methylpiperidine / CH₂Cl₂; toluene / 16 h / Ambient temperature

3: TFA / CH₂Cl₂ / 2 h / 0 °C

4: N-methylpiperidine / CH₂Cl₂; toluene / 16 h / Ambient temperature

With N-methylcyclohexylamine; trifluoroacetic acid; In dichloromethane; toluene;

DOI:10.1021/jm9801096

Reference yield:

N-(tert-buytoxycarbonyl)-N-ethylglycine (149794-10-5) → (S)-3-[2-(tert-Butoxycarbonyl-ethyl-amino)-acetylamino]-N-((S)-1-carbamoyl-2-cyclohexyl-ethyl)-succinamic acid benzyl ester (204139-57-1)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylpiperidine / CH₂Cl₂ / 0.03 h / 0 °C

2: N-methylpiperidine / CH₂Cl₂; toluene / 16 h / Ambient temperature

With N-methylcyclohexylamine; In dichloromethane; toluene;

DOI:10.1021/jm9801096

Reference yield:

(S)-3-tert-Butoxycarbonylamino-4-isopropoxycarbonyloxy-4-oxo-butyric acid benzyl ester (118517-08-1) → (S)-3-[2-(tert-Butoxycarbonyl-ethyl-amino)-acetylamino]-N-((S)-1-carbamoyl-2-cyclohexyl-ethyl)-succinamic acid benzyl ester (204139-57-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N-methylpiperidine / CH₂Cl₂; toluene / 16 h / Ambient temperature

2: TFA / CH₂Cl₂ / 2 h / 0 °C

3: N-methylpiperidine / CH₂Cl₂; toluene / 16 h / Ambient temperature

With N-methylcyclohexylamine; trifluoroacetic acid; In dichloromethane; toluene;

DOI:10.1021/jm9801096

upstream raw materials:

(S)-3-Amino-N-((S)-1-carbamoyl-2-cyclohexyl-ethyl)-succinamic acid benzyl ester

BOC-L-aspartic acid 4-benzyl ester

N-(tert-buytoxycarbonyl)-N-ethylglycine

(S)-3-tert-Butoxycarbonylamino-4-isopropoxycarbonyloxy-4-oxo-butyric acid benzyl ester

Downstream raw materials:

(S)-N-((S)-1-Carbamoyl-2-cyclohexyl-ethyl)-3-(2-ethylamino-acetylamino)-succinamic acid benzyl ester