149794-10-5

Basic information

• Product Name: BOC-N-ETHYL GLYCINE
• Synonyms: N-BOC-N-ETHYL-GLYCINE;BOC-N-ETHYL GLYCINE;BOC-N-ETHYLGLY-OH;N-(tert-Butoxycarbonyl)-N-ethylglycine;2-(tert-butoxycarbonyl(ethyl)amino)acetic acid;Boc-N-ethyl glycine≥ 98% (HPLC)
• CAS NO: 149794-10-5
• Molecular Formula: C₉H₁₇NO₄
• Molecular Weight: 203.24
• Product Categories: Amino Acid Derivatives;Amino Acids
• Mol File: 149794-10-5.mol
• Article Data: 18

Chemical Properties

• Melting Point: 87-88℃
• Boiling Point: 302.729 °C at 760 mmHg
• Flash Point: 136.886 °C
• Appearance: /
• Density: 1.114 g/cm³
• Storage Temp.: Store at 0°C
• PKA: 4.03±0.10(Predicted)
• CAS DataBase Reference: BOC-N-ETHYL GLYCINE(CAS DataBase Reference)
• NIST Chemistry Reference: BOC-N-ETHYL GLYCINE(149794-10-5)
• EPA Substance Registry System: BOC-N-ETHYL GLYCINE(149794-10-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 149794-10-5(Hazardous Substances Data)

Usage

Chemical Properties

White powder

Uses

N-Boc-N-ethyl Glycine, is a substituted Glycine (G615990) used as a building block for the synthesis of more complex pharmaceutical compounds. It can be used for designing potent, selective, orally active, peptide-based fibrinogen receptor antagonists.

Upstream product

• 4530-20-5 BOC-glycine 
• 75-03-6 ethyl iodide 
• 627-01-0 N-ethylglycine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 623-33-6 glycine ethyl ester hydrochloride 
• 1249016-05-4 methyl N-(tert-butoxycarbonyl)-N-ethylglycinate 
• 22889-78-7 3,5-dichloro-4-aminopyridine 
• 98-80-6 phenylboronic acid 
• 6456-74-2 Glycine tert-butyl ester 
• 84532-85-4 methyl 2-(ethylamino)acetate 

Downstream Products

• 1251583-74-0 C₃₂H₄₁ClN₄O₈ 
• 873581-31-8 N-Boc-N-cyclopropylmethyl-L-alanine 
• 1172579-70-2 (S)-2-amino-2-(4-methyltetrahydro-2H-pyran-4-yl)-N-(4-phenyl-1,2,3-thiadiazol-5-yl)acetamide 

Relevant articles and documents

A Naphthalimide-Based Cd2+Fluorescent Probe with Carbamoylmethyl Groups Working as Chelators and PET-Promoters under Neutral Conditions

We have developed a novel naphthalimide-based Cd2+fluorescent probe (1), featuring almost no background response, high sensitivity and selectivity toward Cd2+through its high association constant [K=(2.10±0.423)×106], and a practical working pH range. Membrane-permeability was conferred on 1 by replacing the imide and amide substituents with n-butyl groups, and hence the derivative (4) has found practical utility on fluorescent imaging of Cd2+in HeLa cells. Comparison of fluorescent properties between various compounds derived from 1 has demonstrated that the carbamoylmethyl groups in 1 function not only as Cd2+chelators but also as promoters for photoinduced electron transfer (PET) by lowering the basicity of the two tertiary amino groups. As a result, 1 and 4 exhibited highly practical performance as Cd2+probes under neutral conditions.

HETEROARYL COMPOUNDS

Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

LOCALLY ACTING TOLL-LIKE RECEPTOR 7 (TLR7) AND/OR TLR8 AGONIST IMMUNOTHERAPY COMPOUNDS AND THEIR USES

Provided in the present disclosure are immunotherapy compounds, pharmaceutical compositions thereof and their use, wherein the immunotherapy compounds, upon local administration, form depots inducing cell mediated immune response while mitigating a systemic proinflammatory immune response.