2-[3-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-propoxy]-4-(4-nitro-benzyl)-benzoic acid benzyl ester

Base Information

Chemical Name:2-[3-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-propoxy]-4-(4-nitro-benzyl)-benzoic acid benzyl ester
CAS No.:929603-89-4
Molecular Formula:C₃₄H₄₁N₃O₈
Molecular Weight:619.715
Hs Code.:

2-[3-(2-<i>tert</i>-butoxycarbonylamino-3-methyl-butyrylamino)-propoxy]-4-(4-nitro-benzyl)-benzoic acid benzyl ester

Synonyms:2-[3-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-propoxy]-4-(4-nitro-benzyl)-benzoic acid benzyl ester

Suppliers and Price of 2-[3-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-propoxy]-4-(4-nitro-benzyl)-benzoic acid benzyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-[3-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-propoxy]-4-(4-nitro-benzyl)-benzoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-[3-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-propoxy]-4-(4-nitro-benzyl)-benzoic acid benzyl ester

There total 6 articles about 2-[3-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-propoxy]-4-(4-nitro-benzyl)-benzoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 929603-81-6
2-hydroxy-4-(4-nitro-benzyl)-benzoic acid benzyl ester

: 573968-40-8
(S)-N'-(3'-bromopropyl)-3-methyl-2-(N-tert-butyloxycarbonylamino)butyramide

: 929603-89-4
2-[3-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-propoxy]-4-(4-nitro-benzyl)-benzoic acid benzyl ester

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 6h;
DOI:10.1021/ja0677970

Reference yield:

: 82944-18-1
2,2,7-trimethyl-4H-benzo[d][1,3]dioxin-4-one

: 929603-89-4
2-[3-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-propoxy]-4-(4-nitro-benzyl)-benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 82 percent / N-bromosuccinimide; benzoyl peroxide / CCl₄; H₂O / 2 h / 75 °C

2.1: 87 percent / Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran; H₂O / 3 h / Heating

3.1: 91 percent / trifluoroacetic acid; H₂O / 12 h / 25 °C

4.1: KOH / H₂O

4.2: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 24 h / 20 °C

5.1: 83 percent / Cs₂CO₃ / dimethylformamide / 6 h / 60 °C

With potassium hydroxide; N-Bromosuccinimide; sodium carbonate; caesium carbonate; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; water; N,N-dimethyl-formamide; trifluoroacetic acid; 2.1: Suzuki cross-coupling reaction;
DOI:10.1021/ja0677970

Reference yield:

: 691857-35-9
7-(bromomethyl)-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one

: 929603-89-4
2-[3-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-propoxy]-4-(4-nitro-benzyl)-benzoic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 87 percent / Na₂CO₃ / Pd(PPh₃)4 / tetrahydrofuran; H₂O / 3 h / Heating

2.1: 91 percent / trifluoroacetic acid; H₂O / 12 h / 25 °C

3.1: KOH / H₂O

3.2: 96 percent / tetrabutylammonium fluoride / tetrahydrofuran / 24 h / 20 °C

4.1: 83 percent / Cs₂CO₃ / dimethylformamide / 6 h / 60 °C

With potassium hydroxide; sodium carbonate; caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide; trifluoroacetic acid; 1.1: Suzuki cross-coupling reaction;
DOI:10.1021/ja0677970