2-ethyl-5-((S)-3-methoxybut-1-ynyl)-7-methyl-3-((1S)-5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine

Base Information

• Chemical Name: 2-ethyl-5-((S)-3-methoxybut-1-ynyl)-7-methyl-3-((1S)-5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine
• CAS No.: 1038920-72-7
• Molecular Formula: C₄₉H₄₃N₇O
• Molecular Weight: 745.927

Synonyms:2-ethyl-5-((S)-3-methoxybut-1-ynyl)-7-methyl-3-((1S)-5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine

Chemical Property of 2-ethyl-5-((S)-3-methoxybut-1-ynyl)-7-methyl-3-((1S)-5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine

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Technology Process of 2-ethyl-5-((S)-3-methoxybut-1-ynyl)-7-methyl-3-((1S)-5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine

There total 1 articles about 2-ethyl-5-((S)-3-methoxybut-1-ynyl)-7-methyl-3-((1S)-5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

(S)-4-(2-ethyl-7-methyl-3-((1S)-5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridin-5-yl)but-3-yn-2-ol (1038920-70-5) + methyl iodide (74-88-4) → 2-ethyl-5-((S)-3-methoxybut-1-ynyl)-7-methyl-3-((1S)-5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine (1038920-72-7)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 20 ℃; for 16h;

Reference yield:

2-ethyl-5-((S)-3-methoxybut-1-ynyl)-7-methyl-3-((1S)-5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridine (1038920-72-7) → 3-((1S)-5-(2-(1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-2-ethyl-5-((S)-3-methoxybutyl)-7-methyl-3H-imidazo[4,5-b]pyridine (1038920-69-2)

Guidance literature:

With ammonium formate; palladium 10% on activated carbon; for 16h; Heating / reflux;

upstream raw materials:

(S)-4-(2-ethyl-7-methyl-3-((1S)-5-(2-(1-trityl-1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-3H-imidazo[4,5-b]pyridin-5-yl)but-3-yn-2-ol

methyl iodide

Downstream raw materials:

3-((1S)-5-(2-(1H-tetrazol-5-yl)phenyl)-2,3-dihydro-1H-inden-1-yl)-2-ethyl-5-((S)-3-methoxybutyl)-7-methyl-3H-imidazo[4,5-b]pyridine

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