4-(3-{2-[2-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)-ethoxy]-ethyl}-4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-2-trifluoromethyl-benzonitrile

Base Information

Chemical Name:4-(3-{2-[2-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)-ethoxy]-ethyl}-4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-2-trifluoromethyl-benzonitrile
CAS No.:636595-68-1
Molecular Formula:C₂₈H₂₉F₃N₄O₆
Molecular Weight:574.557
Hs Code.:

4-(3-{2-[2-(2,2-dimethyl-4-oxo-3,4-dihydro-2<i>H</i>-benzo[<i>e</i>][1,3]oxazin-6-ylmethoxy)-ethoxy]-ethyl}-4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-2-trifluoromethyl-benzonitrile

Synonyms:4-(3-{2-[2-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)-ethoxy]-ethyl}-4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-2-trifluoromethyl-benzonitrile

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Chemical Property of 4-(3-{2-[2-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)-ethoxy]-ethyl}-4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-2-trifluoromethyl-benzonitrile

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Technology Process of 4-(3-{2-[2-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)-ethoxy]-ethyl}-4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-2-trifluoromethyl-benzonitrile

There total 5 articles about 4-(3-{2-[2-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)-ethoxy]-ethyl}-4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-2-trifluoromethyl-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 143782-20-1
4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile

: 636595-61-4
methanesulfonic acid 2-[2-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)ethoxy]ethyl ester

: 636595-68-1
4-(3-{2-[2-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)-ethoxy]-ethyl}-4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-2-trifluoromethyl-benzonitrile

Guidance literature:: 4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

methanesulfonic acid 2-[2-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)ethoxy]ethyl ester; In N,N-dimethyl-formamide; at 60 ℃; for 24h;
DOI:10.1021/jm0303305

Reference yield:

: 77-71-4
5,5-dimethyl-imidazolidine-2,4-dione

: 636595-68-1
4-(3-{2-[2-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)-ethoxy]-ethyl}-4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-2-trifluoromethyl-benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: 60 percent / K₂CO₃ / dimethylformamide / 64 h / 55 - 65 °C

2.1: NaH / dimethylformamide / 3 h / 20 °C

2.2: dimethylformamide / 24 h / 60 °C

With sodium hydride; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm0303305

Reference yield:

: 76143-20-9
5-formyl-2-hydroxy-benzamide

: 636595-68-1
4-(3-{2-[2-(2,2-dimethyl-4-oxo-3,4-dihydro-2H-benzo[e][1,3]oxazin-6-ylmethoxy)-ethoxy]-ethyl}-4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-2-trifluoromethyl-benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: 91 percent / decaborane / 5 h / 70 °C

2.1: 88 percent / p-TsOH / acetone / 1.5 h / 80 °C

3.1: 92 percent / pyridine; Et₃N / tetrahydrofuran / 2 h / 20 °C

4.1: NaH / dimethylformamide / 3 h / 20 °C

4.2: dimethylformamide / 24 h / 60 °C

With pyridine; Decaborane; sodium hydride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm0303305