77-71-4

Basic information

• Product Name: 5,5-Dimethylhydantoin
• Synonyms: 4-Imidazolidinedione,5,5-dimethyl-2;5,5-dimethyl-4-imidazolidinedione;5,5-dimethyl-hydantoi;5,5-Dimethyl-imidazolidin-2,4-dion;5,5-Dimethylimidazolidin-2,4-dione;Acetonylurea;Dantoin DMH;dantoindmh
• CAS NO: 77-71-4
• Molecular Formula: C₅H₈N₂O₂
• Molecular Weight: 128.13
• EINECS: 201-051-3
• Product Categories: Miscellaneous Natural Products;Water treatment chemicals;Building Blocks;Heterocyclic Building Blocks;Imidazolines/Imidazolidines;Resin additives
• Mol File: 77-71-4.mol
• Article Data: 51

Chemical Properties

• Melting Point: 174-177 °C(lit.)
• Boiling Point: 237.54°C (rough estimate)
• Flash Point: 193°C
• Appearance: White to off-white/Crystalline Powder or Crystals
• Density: 1.2864 (rough estimate)
• Refractive Index: 1.4730 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: H2O: 0.1 g/mL hot, clear
• PKA: pKa 8.1 (Uncertain)
• Water Solubility: soluble
• BRN: 2827
• CAS DataBase Reference: 5,5-Dimethylhydantoin(CAS DataBase Reference)
• NIST Chemistry Reference: 5,5-Dimethylhydantoin(77-71-4)
• EPA Substance Registry System: 5,5-Dimethylhydantoin(77-71-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 22-24/25-36/37-26
• WGK Germany: 2
• RTECS: MU0977000
• TSCA: Yes
• Hazardous Substances Data: 77-71-4(Hazardous Substances Data)

Usage

Chemical Properties

white to off-white crystals or crystalline powder

Uses

5,5-Dimethylhydantoin is part of a group of hydantoin compounds that are being evaluated for their anticonvulsant and central nervous system antitumour properties.

Purification Methods

Crystallise the hydantoin from EtOH and sublime it in vacuo. [Beilstein 24 III/IV 1097.]

InChI:InChI=1/C5H8N2O2/c1-5(2)3(8)6-4(9)7-5/h1-2H3,(H2,6,7,8,9)

Synthetic route

potassium cyanate (590-28-3) + methyl 2-aminoisobutyrate hydrochloride (15028-41-8) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
Stage #1: potassium cyanate; methyl 2-aminoisobutyrate hydrochloride In water Milling; Green chemistry; Stage #2: With potassium carbonate In water Green chemistry;	92%

potassium cyanide + ammonium carbonate (506-87-6) + acetone (67-64-1) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
In water at 120℃; under 15001.5 Torr; for 0.533333h; Bucherer-Bergs Reaction; Flow reactor;	82%
Stage #1: potassium cyanide; ammonium carbonate; acetone In ethanol; water at 55 - 60℃; Bucherer-Bergs Reaction; Stage #2: With hydrogenchloride In ethanol; water	65%
Stage #1: acetone With sodium metabisulfite Stage #2: potassium cyanide Bucherer-Bergs reaction; Stage #3: ammonium carbonate Bucherer-Bergs reaction;
In ethanol; water at 50 - 80℃; Reflux;

2,3:4,5-bis-O-(isopropylidene)-D-fructopyranose aldehyde (32786-02-0) + ammonium carbonate → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + 3,4:5,6-di-O-isopropylidene-β-D-arabino-DL-glycero-3-heptulopyranosonitrile (116730-70-2, 116730-73-5) + 3,4:5,6-di-O-isopropylidene-β-D-arabino-DL-glycero-3-heptulopyranosoamide (116730-72-4, 116730-76-8)

Conditions	Yield
With potassium cyanide In ethanol; water at 50℃; for 72h;	A 77.8% B 2% C 7.3%

5-[(R)-2-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-eth-(Z)-ylidene]-imidazolidine-2,4-dione (116730-53-1) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + 5-(D-threo-2,3,4-trihydroxybutylidene)imidazol-2,4-dione (116730-55-3)

Conditions	Yield
hydrolysis; Yield given;	A 62.5% B n/a

2,3:4,5-di-O-isopropylidene-D-xylose (3673-15-2, 13039-93-5, 13039-94-6, 23568-31-2, 50866-82-5, 81801-10-7, 120522-08-9, 120522-09-0, 120522-10-3) + ammonium carbonate → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + 5-(D-threo-2,3,4-trihydroxybutylidene)imidazol-2,4-dione (116730-55-3)

Conditions	Yield
With potassium cyanide In ethanol; water at 50℃; for 24h;	A 62.5% B 15%

2,3:4,5-di-O-isopropylidene-D-xylose (3673-15-2, 13039-93-5, 13039-94-6, 23568-31-2, 50866-82-5, 81801-10-7, 120522-08-9, 120522-09-0, 120522-10-3) + ammonium carbonate → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + 5-[(R)-2-((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-2-hydroxy-eth-(Z)-ylidene]-imidazolidine-2,4-dione (116730-53-1)

Conditions	Yield
With potassium cyanide In ethanol; water at 50℃; for 24h;	A 62.5% B n/a

carbonic-acid (463-79-6) + 2-amino-2-cyanopropane (19355-69-2) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
at 25℃; for 24h;	50%

(3aR,5S,5aR,8aS,8bR)-2,2,7,7-Tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-carbaldehyde (4933-77-1) + ammonium carbonate → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + 5-(4,5-isopropylidene-L-gluconor-L-mannono-nitrile-6-yl)hydantoin (116730-74-6, 116837-98-0) + 5-<1,2:3,4-di-O-isopropylidene-α-D-galacto-pentopyranose-5(R)-yl>hydantoin (116730-68-8) + 6-deoxy-1,2:3,4-di-O-isopropylidene-6-ureido-DL-glycero-α-D-galacto-heptopyranuronamide (116730-54-2, 116730-69-9)

Conditions	Yield
With potassium cyanide In ethanol; water at 50℃; for 24h;	A 45% B 2% C 15.7% D 23%

1H-imidazole (288-32-4) + 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione (77-48-5) → 4-bromo-1 H-imidazole (2302-25-2) + 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
With sulfuric acid In water at 0℃; for 0.0833333h;	A 21% B 33%

3,4-dihydro-4,4,6-trimethylpyrimidine-2(1H)-thione (5392-23-4) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
With potassium permanganate; water

2-amino-2-methylpropanamide (16252-90-7) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
With ethanol; carbon dioxide

2-cyano-2-methylpropanamide (7505-93-3) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
With potassium hypobromite

(1-Cyan-1-methylethyl)harnstoff (79662-84-3) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
With hydrogenchloride

N-carbamoyl-α-aminoisobutyric acid (38605-63-9) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
at 130 - 140℃;
With hydrogenchloride
With hydrogenchloride at 50℃; Rate constant;

ethyl 2-isocyanato-2-methylpropionate (128326-91-0) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
With ammonium hydroxide anschliessende Cyclisierung mit wss.HCl;

dimethyl-malonic acid bis-bromoamide (861329-91-1) + sodium methylate (124-41-4) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
erst in der Kaelte, dann in der Hitze;

dimethyl-malonic acid bis-bromoamide (861329-91-1) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
With sodium methylate

2-Aminoisobutyric acid (62-57-7) + urea (57-13-6) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
at 160 - 170℃;

ammonium carbamate (1111-78-0) + 2-hydroxy-2-methylpropanenitrile (75-86-5) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
at 50 - 65℃;

sodium cyanide (143-33-9) + acetone (67-64-1) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
With ethanol; carbon dioxide; ammonia
With water; ammonium carbonate
With carbon dioxide; water; ammonium carbonate

potassium cyanide (151-50-8) + acetone (67-64-1) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
With hydrogenchloride; potassium cyanate
With water; ammonium carbonate
With hydrogenchloride; potassium cyanate
With carbon dioxide; water; ammonium carbonate

2-amino-2-cyanopropane (19355-69-2) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
With carbon dioxide; water

1,3-dibromo-5,5-dimethyl-hydantoin (7072-23-3) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
With hydrogenchloride; ascorbic acid In water at 30℃;

(1-Carbamoyl-1-methyl-ethyl)-carbamic acid ethyl ester (81587-19-1) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
With sodium hydroxide In methanol for 1.5h; Ambient temperature;

tert-butyl (1-amino-2-methyl-1-oxopropan-2-yl)carbamate (73470-46-9) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
With sodium hydroxide In methanol for 1.5h; Ambient temperature;

benzyl N-(2-amino-1,1-dimethyl-2-oxo-ethyl)carbamate (81587-18-0) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
With sodium hydroxide In methanol for 1.5h; Ambient temperature;

1,3-di(chlorothio)-5,5-dimethylhydantoin (104867-38-1) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
With water

chlorohydantoin → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
With arsenic(III); potassium iodide In water other reductants;

N-bromo-N'-chloro-5,5-dimethylhydantoin (16079-88-2) → 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4)

Conditions	Yield
With hydrogenchloride; potassium bromide; hydrazine In acetic acid at 32℃; Product distribution; other reductants;

morpholine (110-91-8) + formaldehyd (50-00-0) + 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) → 5,5-Dimethyl-3-<(morpholin-4-yl)methyl>imidazolidin-2,4-dion (951-13-3)

Conditions	Yield
With 4 A molecular sieve In N,N-dimethyl-formamide for 15h; Ambient temperature;	100%
In methanol for 2h; Condensation;	98%
In ethanol	71%

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) → 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione (77-48-5)

Conditions	Yield
With bromine	99%
With bromine	99%
With bromine	99%

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) → 1,3-dichloro-5,5-dimethylhydantoin (118-52-5)

Conditions	Yield
Stage #1: 5,5-dimethyl-imidazolidine-2,4-dione With sodium carbonate at 20℃; for 6h; Stage #2: With chlorine In tetrahydrofuran; ethyl acetate at 100℃; for 7h; Concentration; Microwave irradiation;	98.72%
With trichloroisocyanuric acid In acetonitrile at 20℃; for 0.5h;	87%
With water; chlorine at 8 - 10℃;

Di-tert-butyl acetylenedicarboxylate (66086-33-7) + 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + triphenylphosphine (603-35-0) → di-tert-butyl 2-(4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-3-(triphenylphosphanylidene)-succinate

Conditions	Yield
In ethyl acetate at 20℃; for 8h;	98%

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + 4-cyanobenzyl bromide (17201-43-3) → 4-((4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)methyl)benzonitrile (164648-32-2)

Conditions	Yield
potassium tert-butylate	98%
With potassium carbonate In N,N-dimethyl-formamide at 0 - 20℃; for 12h;	53.5%

4-iodo-2-(trifluoromethyl)benzonitrile (101066-87-9) + 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) → 4-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)-2-(trifluoromethyl)benzonitrile (143782-20-1)

Conditions	Yield
With copper(I) oxide In N,N-dimethyl-formamide at 150℃; for 12h;	98%
With copper(I) oxide In N,N-dimethyl-formamide at 150℃; for 12h;	98%
With copper(I) oxide In N,N-dimethyl-formamide at 150℃; for 14h; Inert atmosphere; regioselective reaction;	82%

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + benzyl alcohol (100-51-6) → 3-benzoyl-5,5-dimethylimidazolidine-2,4-dione (1886-18-6)

Conditions	Yield
With iron(III) chloride; calcium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; sodium hydrogencarbonate In water; acetonitrile at 35℃; for 1.5h; Sealed tube; Inert atmosphere;	98%

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + silver nitrate → Ag(1+)*C5H7N2O2(1-)=AgC5H7N2O2

Conditions	Yield
In not given	97%

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + cyclohexane-1,2-epoxide (286-20-4) → 3-(2-hydroxy-cyclohexyl)-5,5-dimethyl-imidazolidine-2,4-dione (40388-38-3)

Conditions	Yield
With lithium chloride In N-methyl-acetamide	96.4%

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) → N-bromo-N'-chloro-5,5-dimethylhydantoin (16079-88-2)

Conditions	Yield
Stage #1: 5,5-dimethyl-imidazolidine-2,4-dione With bromine; sodium hydroxide In water at 5 - 10℃; for 0.25h; Large scale; Stage #2: With chlorine In water for 0.5h; Temperature; Reagent/catalyst; Large scale;	96.3%
With sodium hydroxide; bromine; chlorine In dichloromethane; water
With sodium hydroxide; bromine; chlorine In dichloromethane

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → 5,5-dimethyl-1,3-bis(TMS)hydantoin (66448-28-0)

Conditions	Yield
In 1,2-dichloro-ethane for 15h; Heating;	96%

N-(oxiran-2-ylmethyl)-N-ethylaniline (19614-67-6) + 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) → 3-(5,5-dimethylhydantoin-3-yl)-1-(N-ethylanilino)propan-2-ol (1258220-60-8)

Conditions	Yield
In ethanol at 20 - 150℃; for 19h;	96%

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + hex-1-yne (693-02-7) → 3-[(Z)-hex-1-en-1-yl]-1,5,5-trimethylimidazolidine-2,4-dione

Conditions	Yield
With [bis(2-methylallyl)cycloocta-1,5-diene]ruthenium(II); 1,4-bis(dicyclohexylphosphino)butane; ytterbium(III) triflate In N,N-dimethyl-formamide at 60℃; for 16h; Inert atmosphere; optical yield given as %de;	96%

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + dimethyl acetylenedicarboxylate (762-42-5) + triphenylphosphine (603-35-0) → dimethyl 2-(4,4-dimethyl-2,5-dioxo-imidazolidin-1-yl)-3-(triphenylphosphanylidene)-succinate

Conditions	Yield
In ethyl acetate at 20℃; for 8h;	95%

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + benzyl chloride (100-44-7) → 3-benzyl-5,5-dimethyl-2,4-imidazolidinedione (34657-68-6)

Conditions	Yield
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃;	94%
With potassium carbonate In DMF (N,N-dimethyl-formamide) at 20℃;	94%
With sodium hydride In N,N-dimethyl-formamide for 15h; Ambient temperature;	53%

methanol (67-56-1) + 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) → methyl N-isopropylallophanate (84039-99-6)

Conditions	Yield
for 30h; Irradiation;	93%

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + p-methoxybenzyl chloride (824-94-2) → 3-(4-methoxybenzyl)-5,5-dimethylimidazolidine-2,4-dione (220615-80-5)

Conditions	Yield
With potassium carbonate In acetonitrile at 20℃; for 8h; Inert atmosphere;	93%
With potassium carbonate In N,N-dimethyl-formamide at 20℃; for 16h;	88.5%
Stage #1: 5,5-dimethyl-imidazolidine-2,4-dione With potassium hydroxide In ethanol at 25 - 90℃; Stage #2: p-methoxybenzyl chloride In methanol; ethanol at 25 - 60℃;	14%

1,8-dibromooctane (4549-32-0) + 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) → C13H23BrN2O2

Conditions	Yield
Stage #1: 5,5-dimethyl-imidazolidine-2,4-dione With potassium carbonate In acetone at 20℃; for 0.5h; Stage #2: 1,8-dibromooctane In acetone at 20℃; for 3h;	92.4%
Stage #1: 5,5-dimethyl-imidazolidine-2,4-dione With potassium carbonate In acetone for 0.5h; Reflux; Stage #2: 1,8-dibromooctane In acetone Reflux;	92.4%

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + allyl bromide (106-95-6) → 1-(Prop-2-enyl)-4,4-dimethyl-2,5-dioxoimidazolidine (3366-92-5)

Conditions	Yield
With potassium hydroxide In methanol; water at 60℃; for 2h;	92%
Stage #1: 5,5-dimethyl-imidazolidine-2,4-dione With sodium hydroxide In water Stage #2: allyl bromide In methanol; water at 60℃; for 1h;	90%
With triethylamine In tetrahydrofuran for 5h; Addition; Heating;

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + 1-Bromo-2-chloroethane (107-04-0) → 3-(2'-chloroethyl)-5, 5-dimethylhydantoin (53066-53-8)

Conditions	Yield
With potassium hydroxide In ethanol at 80℃; for 8h;	92%
With potassium hydroxide In ethanol at 80℃; for 8h;	92%
Stage #1: 5,5-dimethyl-imidazolidine-2,4-dione With sodium hydroxide In ethanol at 90℃; for 0.166667h; Stage #2: 1-Bromo-2-chloroethane In ethanol at 80℃; for 8h;	87.6%

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + Ethyl 2-bromopropionate (535-11-5, 41978-69-2) → 2-(4,4-dimethyl-2,5-dioxoimidazolidin-1-yl)propionic acid ethyl ester (127834-98-4)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 85℃; for 90h; Inert atmosphere; regioselective reaction;	92%

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + benzyl bromide (100-39-0) → 3-benzyl-5,5-dimethyl-2,4-imidazolidinedione (34657-68-6)

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 85℃; for 6h; Inert atmosphere; regioselective reaction;	92%
Stage #1: 5,5-dimethyl-imidazolidine-2,4-dione With potassium carbonate In acetone for 0.5h; Reflux; Stage #2: benzyl bromide In acetone at 20℃; for 21h; Reflux;	73%

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + bis(4-methylphenyl)iodonium trifluoromethanesulfonate (123726-16-9) → 5,5-dimethyl-3-(p-tolyl)imidazolidine-2,4-dione (92668-56-9)

Conditions	Yield
With potassium phosphate; copper(l) iodide In 1,2-dichloro-ethane at 20℃; for 7h; Inert atmosphere; Schlenk technique; Sealed tube;	92%

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) + benzyl bromide (100-39-0) → 3-benzyl-1-(3-iodo-2-propynyl-5,5-dimethylhydantoin + 3-benzyl-5,5-dimethyl-2,4-imidazolidinedione (34657-68-6)

Conditions	Yield
With potassium carbonate In acetone	A 91.3% B n/a

2-bromonaphthalene (580-13-2) + 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) → 5,5-dimethyl-3-(naphthalen-2-yl)hydantoin

Conditions	Yield
With copper(I) oxide In N,N-dimethyl-formamide at 150℃; for 14h; Inert atmosphere; regioselective reaction;	91%

(3-chloropropyl)triethoxysilane (5089-70-3) + 5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) → 5,5-dimethyl-3-(3'-triethoxysilylpropyl)hydantoin (473780-80-2)

Conditions	Yield
Stage #1: 5,5-dimethyl-imidazolidine-2,4-dione With potassium hydroxide In ethanol Heating / reflux; Stage #2: (3-chloropropyl)triethoxysilane In DMF (N,N-dimethyl-formamide) at 60 - 95℃; for 5h;	90.3%
Stage #1: 5,5-dimethyl-imidazolidine-2,4-dione With sodium hydroxide In ethanol at 90℃; for 0.166667h; Stage #2: (3-chloropropyl)triethoxysilane In N,N-dimethyl-formamide at 95℃; for 10h;

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) → 1,3-Diiodo-5,5-dimethyl-2,4-imidazolidinedione (2232-12-4)

Conditions	Yield
With sodium hypochlorite; iodine In acetic acid butyl ester; water at 10℃; for 2h; Solvent; Reagent/catalyst;	90%
With Iodine monochloride; sodium hydroxide In chloroform; water at -5 - 5℃; for 2h;	63.3%
With sodium hydroxide; Iodine monochloride In chloroform at 0℃; for 0.25h;	48%

5,5-dimethyl-imidazolidine-2,4-dione (77-71-4) → 3-amino-5,5'-dimethylimidazolidine-2,4-dione (1123-44-0)

Conditions	Yield
With hydrazine hydrate	90%
With hydrazine hydrate
With hydrazine hydrate Heating;
With hydrazine hydrate

Upstream product

• 506-87-6 Ammonium carbonate 

Downstream Products

• 77-48-5 1,3-Dibromo-5,5-dimethylhydantoin 

Recommend Products

• 5392-23-4  3,4-dihydro-4,4,6-trimethylpyrimidine-2(1H)-thione 
• 16252-90-7  2-amino-2-methylpropanamide 
• 7505-93-3  2-cyano-2-methylpropanamide 
• 38605-63-9  N-carbamoyl-α-aminoisobutyric acid 
• 861329-91-1  dimethyl-malonic acid bis-bromoamide 
• 124-41-4  sodium methylate 
• 62-57-7  2-Aminoisobutyric acid 
• 57-13-6  urea 
• 1111-78-0  ammonium carbamate 
• 75-86-5  2-hydroxy-2-methylpropanenitrile 
• 143-33-9  sodium cyanide 
• 67-64-1  acetone 
• 151-50-8  potassium cyanide 
• 7072-23-3  1,3-dibromo-5,5-dimethyl-hydantoin