N-(3,4-difluorophenyl)-2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxamide

Base Information

• Chemical Name: N-(3,4-difluorophenyl)-2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxamide
• CAS No.: 1468402-81-4
• Molecular Formula: C₁₉H₁₁F₄NO₂
• Molecular Weight: 361.295
• Mol file: 1468402-81-4.mol

Synonyms:N-(3,4-difluorophenyl)-2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxamide

Chemical Property of N-(3,4-difluorophenyl)-2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3,4-difluorophenyl)-2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxamide

There total 7 articles about N-(3,4-difluorophenyl)-2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid (22494-42-4) + 3,4-difluoroaniline (3863-11-4) → N-(3,4-difluorophenyl)-2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxamide (1468402-81-4)

Guidance literature:

2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid; With thionyl chloride; In tetrahydrofuran; for 8h; Reflux; Inert atmosphere;

3,4-difluoroaniline; In tetrahydrofuran; for 14h;

Reference yield:

C13H7ClF2O2 (344348-56-7) + 3,4-difluoroaniline (3863-11-4) → N-(3,4-difluorophenyl)-2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxamide (1468402-81-4)

Guidance literature:

In tetrahydrofuran; Inert atmosphere; Reflux;

DOI:10.1016/j.ejmech.2015.05.015

Reference yield:

2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid (22494-42-4) → N-(3,4-difluorophenyl)-2',4'-difluoro-4-hydroxy-[1,1'-biphenyl]-3-carboxamide (1468402-81-4)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / tetrahydrofuran / 8 h / Reflux; Inert atmosphere

2: tetrahydrofuran / Inert atmosphere; Reflux

With thionyl chloride; In tetrahydrofuran;

DOI:10.1016/j.ejmech.2015.05.015

upstream raw materials:

2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid

3,4-difluoroaniline

2-hydroxy-5-iodobenzoic acid

C₁₃H₇ClF₂O₂

Downstream raw materials:

6-(2,4-difluorophenyl)-3-(3,4-difluorophenyl)-2H-benzo[e][1,3]oxazine-2,4(3H)-dione