(1S,2R)-N-(4-chlorobenzyl)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropanacetamide

Base Information

Chemical Name:(1S,2R)-N-(4-chlorobenzyl)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropanacetamide
CAS No.:910630-41-0
Molecular Formula:C₃₄H₃₀ClN₃O
Molecular Weight:532.085
Hs Code.:

Synonyms:(1S,2R)-N-(4-chlorobenzyl)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropanacetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,2R)-N-(4-chlorobenzyl)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropanacetamide

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Technology Process of (1S,2R)-N-(4-chlorobenzyl)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropanacetamide

There total 4 articles about (1S,2R)-N-(4-chlorobenzyl)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropanacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 910630-38-5
(1S,2R)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropaneacetic acid

: 104-86-9
4-chlorobenzylamine

: 910630-41-0
(1S,2R)-N-(4-chlorobenzyl)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropanacetamide

Guidance literature:: With dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In dichloromethane; at 20 ℃;
DOI:10.1021/jm0603318

Reference yield:

: 4-[2-(2-methoxy-vinyl)-cyclopropyl]-1-trityl-1H-imidazole

: 910630-41-0
(1S,2R)-N-(4-chlorobenzyl)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropanacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 301 mg / aq. HCl / acetone / 0 h / 20 °C

2: 98 percent / NaClO₂; NaH₂PO₄*2H₂O; 2-methyl-2-butene / tetrahydrofuran; 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

3: 78 percent / EDC; DMAP / CH₂Cl₂ / 20 °C

With hydrogenchloride; dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; water; acetone; tert-butyl alcohol;
DOI:10.1021/jm0603318

Reference yield:

: 910630-37-4
(1S,2R)-2-formylmethyl-1-(1-triphenylmethyl-1H-imidazol-4-yl)cyclopropane

: 910630-41-0
(1S,2R)-N-(4-chlorobenzyl)-1-(1-triphenylmethyl-1H-imidazol-4-yl)-2-cyclopropanacetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 98 percent / NaClO₂; NaH₂PO₄*2H₂O; 2-methyl-2-butene / tetrahydrofuran; 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

2: 78 percent / EDC; DMAP / CH₂Cl₂ / 20 °C

With dmap; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; water; tert-butyl alcohol;
DOI:10.1021/jm0603318