tert-butyl 3-((3,5-bis(trifluoromethyl)benzylamino)methyl)-2-ethyl-6-(trifluoromethyl)indoline-1-carboxylate

Base Information

Chemical Name:tert-butyl 3-((3,5-bis(trifluoromethyl)benzylamino)methyl)-2-ethyl-6-(trifluoromethyl)indoline-1-carboxylate
CAS No.:880558-45-2
Molecular Formula:C₂₆H₂₇F₉N₂O₂
Molecular Weight:570.498
Hs Code.:

Synonyms:tert-butyl 3-((3,5-bis(trifluoromethyl)benzylamino)methyl)-2-ethyl-6-(trifluoromethyl)indoline-1-carboxylate

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Chemical Property of tert-butyl 3-((3,5-bis(trifluoromethyl)benzylamino)methyl)-2-ethyl-6-(trifluoromethyl)indoline-1-carboxylate

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Technology Process of tert-butyl 3-((3,5-bis(trifluoromethyl)benzylamino)methyl)-2-ethyl-6-(trifluoromethyl)indoline-1-carboxylate

There total 1 articles about tert-butyl 3-((3,5-bis(trifluoromethyl)benzylamino)methyl)-2-ethyl-6-(trifluoromethyl)indoline-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.7%

: 880558-42-9
tert-butyl 2-ethyl-6-(trifluoromethyl)-3-formylindoline-1-carboxylate

: 85068-29-7
3,5-bis-trifluoromethylbenzylamine

: 880558-45-2
tert-butyl 3-((3,5-bis(trifluoromethyl)benzylamino)methyl)-2-ethyl-6-(trifluoromethyl)indoline-1-carboxylate

Guidance literature:: tert-butyl 2-ethyl-6-(trifluoromethyl)-3-formylindoline-1-carboxylate; 3,5-bis-trifluoromethylbenzylamine; With Si-CNBH₃; acetic acid; In tetrahydrofuran; at 20 ℃; not specified

With sodium hydrogencarbonate; In tetrahydrofuran; water; ethyl acetate; Saturated solution;

Reference yield:

: 880558-45-2
tert-butyl 3-((3,5-bis(trifluoromethyl)benzylamino)methyl)-2-ethyl-6-(trifluoromethyl)indoline-1-carboxylate

: 75-36-5
acetyl chloride

: 880556-89-8
tert-butyl 3-((N-(3,5-bis(trifluoromethyl)benzyl)acetamido)methyl)-2-ethyl-6-(trifluoromethyl)indoline-1-carboxylate

Guidance literature:: tert-butyl 3-((3,5-bis(trifluoromethyl)benzylamino)methyl)-2-ethyl-6-(trifluoromethyl)indoline-1-carboxylate; acetyl chloride; With pyridine; In dichloromethane; at 20 ℃; for 4h;

With PS-Trisamine scavenger reagent; In dichloromethane;

Reference yield:

: 880558-45-2
tert-butyl 3-((3,5-bis(trifluoromethyl)benzylamino)methyl)-2-ethyl-6-(trifluoromethyl)indoline-1-carboxylate

: 79-22-1
methyl chloroformate

: 880556-91-2
methyl (1-(tert-butoxycarbonyl)-2-ethyl-6-(trifluoromethyl)indolin-3-yl)methyl 3,5-bis(trifluoromethyl)benzylcarbamate

Guidance literature:: tert-butyl 3-((3,5-bis(trifluoromethyl)benzylamino)methyl)-2-ethyl-6-(trifluoromethyl)indoline-1-carboxylate; methyl chloroformate; With pyridine; In dichloromethane; at 20 ℃; for 4h;

With PS-Trisamine scavenger reagent; In dichloromethane;