(Z)-1-tert-butyldimethylsilyloxy-9-(4-methylphenylsulfonamido)non-4-ene-2,6-diyne

Base Information

Chemical Name:(Z)-1-tert-butyldimethylsilyloxy-9-(4-methylphenylsulfonamido)non-4-ene-2,6-diyne
CAS No.:195608-40-3
Molecular Formula:C₂₂H₃₁NO₃SSi
Molecular Weight:417.645
Hs Code.:

Synonyms:(Z)-1-tert-butyldimethylsilyloxy-9-(4-methylphenylsulfonamido)non-4-ene-2,6-diyne

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Chemical Property of (Z)-1-tert-butyldimethylsilyloxy-9-(4-methylphenylsulfonamido)non-4-ene-2,6-diyne

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Technology Process of (Z)-1-tert-butyldimethylsilyloxy-9-(4-methylphenylsulfonamido)non-4-ene-2,6-diyne

There total 5 articles about (Z)-1-tert-butyldimethylsilyloxy-9-(4-methylphenylsulfonamido)non-4-ene-2,6-diyne which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 76782-82-6
tert-Butyldimethyl(prop-2-ynyloxy)silane

: 195608-39-0
(Z)-1-(4-methylphenylsulfonamido)-6-chlorohex-5-en-3-yne

: 195608-40-3
(Z)-1-tert-butyldimethylsilyloxy-9-(4-methylphenylsulfonamido)non-4-ene-2,6-diyne

Guidance literature:: (Z)-1-(4-methylphenylsulfonamido)-6-chlorohex-5-en-3-yne; With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-butylamine; In benzene; for 0.416667h;

tert-Butyldimethyl(prop-2-ynyloxy)silane; In benzene; at 40 ℃; for 3h;

Reference yield:

: 114534-21-3
(Z)-6-chlorohex-5-en-3-yn-1-ol

: 195608-40-3
(Z)-1-tert-butyldimethylsilyloxy-9-(4-methylphenylsulfonamido)non-4-ene-2,6-diyne

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / Et₃N / CH₂Cl₂ / 0.25 h / 20 °C

2: 80 percent / NaN₃ / dimethylformamide / 4 h / 20 °C

3: aq. PPh₃ / tetrahydrofuran / 20 h / 20 °C

4: 200 mg / DMAP / CH₂Cl₂ / 3 h

5: 70 percent / n-BuNH₂; CuI / Pd(PPh₃)4 / benzene / 3 h / 40 °C

With dmap; copper(l) iodide; sodium azide; N-butylamine; triethylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene; 1: Substitution / 2: Substitution / 3: Reduction / 4: Tosylation / 5: Alkylation;
DOI:10.1039/b000963f

Reference yield:

: 292152-94-4
(Z)-6-chlorohex-5-en-3-ynyl methanesulfonate

: 195608-40-3
(Z)-1-tert-butyldimethylsilyloxy-9-(4-methylphenylsulfonamido)non-4-ene-2,6-diyne

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / NaN₃ / dimethylformamide / 4 h / 20 °C

2: aq. PPh₃ / tetrahydrofuran / 20 h / 20 °C

3: 200 mg / DMAP / CH₂Cl₂ / 3 h

4: 70 percent / n-BuNH₂; CuI / Pd(PPh₃)4 / benzene / 3 h / 40 °C

With dmap; copper(l) iodide; sodium azide; N-butylamine; triphenylphosphine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; benzene; 1: Substitution / 2: Reduction / 3: Tosylation / 4: Alkylation;
DOI:10.1039/b000963f