7-butyl-6-[3-ethynyl-4-(tetrahydropyran-2-yloxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine

Base Information

Chemical Name:7-butyl-6-[3-ethynyl-4-(tetrahydropyran-2-yloxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine
CAS No.:1123659-46-0
Molecular Formula:C₂₃H₂₅N₃O₂
Molecular Weight:375.47
Hs Code.:

Synonyms:7-butyl-6-[3-ethynyl-4-(tetrahydropyran-2-yloxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine

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Chemical Property of 7-butyl-6-[3-ethynyl-4-(tetrahydropyran-2-yloxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine

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Technology Process of 7-butyl-6-[3-ethynyl-4-(tetrahydropyran-2-yloxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine

There total 1 articles about 7-butyl-6-[3-ethynyl-4-(tetrahydropyran-2-yloxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1123659-41-5
4-(tetrahydropyran-2-yloxy)-3-trimethylsilanylethynylbenzonitrile

: 6303-75-9
2-pentylpyrazine

: 1123659-46-0
7-butyl-6-[3-ethynyl-4-(tetrahydropyran-2-yloxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine

: 1123659-44-8
7-butyl-6-[4-(tetrahydropyran-2-yloxy)-3-trimethylsilanylethynylphenyl]-5H-pyrrolo[2,3-b]pyrazine

Guidance literature:: 4-(tetrahydropyran-2-yloxy)-3-trimethylsilanylethynylbenzonitrile; 2-pentylpyrazine; With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -40 - 20 ℃; for 19h; Inert atmosphere;

With water; ammonium chloride; In tetrahydrofuran; hexane;
DOI:10.1016/j.tetlet.2008.11.051

Reference yield: 86.0%

: 1123659-46-0
7-butyl-6-[3-ethynyl-4-(tetrahydropyran-2-yloxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine

: 178685-33-1
8-azido-3,6-dioxaoctyl tosylate

: 1123659-48-2
2-[2-(2-{4-[5-(7-butyl-5H-pyrrolo[2,3-b]pyrazin-6-yl)-2-(tetrahydropyran-2-yloxy)phenyl][1,2,3]triazol-1-yl}ethoxy)ethoxy]ethyl p-toluenesulfonate

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 14.3h;
DOI:10.1016/j.tetlet.2008.11.051

Reference yield:

: polymer-supported azide

: 1123659-46-0
7-butyl-6-[3-ethynyl-4-(tetrahydropyran-2-yloxy)phenyl]-5H-pyrrolo[2,3-b]pyrazine

: C₂₃H₂₅N₆O₂Pol

Guidance literature:: With copper(l) iodide; N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; solid phase reaction;
DOI:10.1016/j.tetlet.2008.11.051