3-methoxy-5-methyl-naphthalene-1-carboxylic acid {[[1-acetyl-2-(tert-butyl-dimethyl-silanyloxy)-2-cyano-ethylcarbamoyl]-(3,4-bis-benzyloxy-5-methanesulfonyloxymethyl-pyrrolidin-2-ylidene)-methyl]-carbamoyl}-(2-methyl-oxiranyl)-methyl ester

Base Information

Chemical Name:3-methoxy-5-methyl-naphthalene-1-carboxylic acid {[[1-acetyl-2-(tert-butyl-dimethyl-silanyloxy)-2-cyano-ethylcarbamoyl]-(3,4-bis-benzyloxy-5-methanesulfonyloxymethyl-pyrrolidin-2-ylidene)-methyl]-carbamoyl}-(2-methyl-oxiranyl)-methyl ester
CAS No.:205442-00-8
Molecular Formula:C₅₁H₆₂N₄O₁₃SSi
Molecular Weight:999.224
Hs Code.:

3-methoxy-5-methyl-naphthalene-1-carboxylic acid {[[1-acetyl-2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-2-cyano-ethylcarbamoyl]-(3,4-bis-benzyloxy-5-methanesulfonyloxymethyl-pyrrolidin-2-ylidene)-methyl]-carbamoyl}-(2-methyl-oxiranyl)-methyl ester

Synonyms:3-methoxy-5-methyl-naphthalene-1-carboxylic acid {[[1-acetyl-2-(tert-butyl-dimethyl-silanyloxy)-2-cyano-ethylcarbamoyl]-(3,4-bis-benzyloxy-5-methanesulfonyloxymethyl-pyrrolidin-2-ylidene)-methyl]-carbamoyl}-(2-methyl-oxiranyl)-methyl ester

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Chemical Property of 3-methoxy-5-methyl-naphthalene-1-carboxylic acid {[[1-acetyl-2-(tert-butyl-dimethyl-silanyloxy)-2-cyano-ethylcarbamoyl]-(3,4-bis-benzyloxy-5-methanesulfonyloxymethyl-pyrrolidin-2-ylidene)-methyl]-carbamoyl}-(2-methyl-oxiranyl)-methyl ester

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Technology Process of 3-methoxy-5-methyl-naphthalene-1-carboxylic acid {[[1-acetyl-2-(tert-butyl-dimethyl-silanyloxy)-2-cyano-ethylcarbamoyl]-(3,4-bis-benzyloxy-5-methanesulfonyloxymethyl-pyrrolidin-2-ylidene)-methyl]-carbamoyl}-(2-methyl-oxiranyl)-methyl ester

There total 6 articles about 3-methoxy-5-methyl-naphthalene-1-carboxylic acid {[[1-acetyl-2-(tert-butyl-dimethyl-silanyloxy)-2-cyano-ethylcarbamoyl]-(3,4-bis-benzyloxy-5-methanesulfonyloxymethyl-pyrrolidin-2-ylidene)-methyl]-carbamoyl}-(2-methyl-oxiranyl)-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 205441-99-2
C₅₅H₆₆N₄O₁₅SSi

: 205442-00-8
3-methoxy-5-methyl-naphthalene-1-carboxylic acid {[[1-acetyl-2-(tert-butyl-dimethyl-silanyloxy)-2-cyano-ethylcarbamoyl]-(3,4-bis-benzyloxy-5-methanesulfonyloxymethyl-pyrrolidin-2-ylidene)-methyl]-carbamoyl}-(2-methyl-oxiranyl)-methyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; acetic acid; triphenylphosphine; In dimethyl sulfoxide;
DOI:10.1016/S0040-4020(03)00379-X

Reference yield:

: 205441-79-8
(3S,4R)-3-Amino-2-(tert-butyl-dimethyl-silanyloxy)-4-(4-methoxy-benzyloxy)-pentanenitrile

: 205442-00-8
3-methoxy-5-methyl-naphthalene-1-carboxylic acid {[[1-acetyl-2-(tert-butyl-dimethyl-silanyloxy)-2-cyano-ethylcarbamoyl]-(3,4-bis-benzyloxy-5-methanesulfonyloxymethyl-pyrrolidin-2-ylidene)-methyl]-carbamoyl}-(2-methyl-oxiranyl)-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 78 percent / tetrahydrofuran / 0.67 h / 50 °C / vacuum

2: 94 percent / DDQ / CH₂Cl₂ / 1 h / 20 °C

3: 98 percent / Dess-Martin reagent / CH₂Cl₂ / 1 h / 20 °C

4: 89 percent / PPh₃; Pd(PPh₃)4; AcOH / dimethylsulfoxide

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; Dess-Martin periodane; acetic acid; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1016/S0040-4020(03)00379-X

Reference yield:

: 205441-96-9
{(S)-2-(tert-Butyl-dimethyl-silanyloxy)-2-cyano-1-[(R)-1-(4-methoxy-benzyloxy)-ethyl]-ethyl}-carbamic acid 9H-fluoren-9-ylmethyl ester

: 205442-00-8
3-methoxy-5-methyl-naphthalene-1-carboxylic acid {[[1-acetyl-2-(tert-butyl-dimethyl-silanyloxy)-2-cyano-ethylcarbamoyl]-(3,4-bis-benzyloxy-5-methanesulfonyloxymethyl-pyrrolidin-2-ylidene)-methyl]-carbamoyl}-(2-methyl-oxiranyl)-methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: piperidine / dimethylformamide / 1 h / 20 °C

2: 78 percent / tetrahydrofuran / 0.67 h / 50 °C / vacuum

3: 94 percent / DDQ / CH₂Cl₂ / 1 h / 20 °C

4: 98 percent / Dess-Martin reagent / CH₂Cl₂ / 1 h / 20 °C

5: 89 percent / PPh₃; Pd(PPh₃)4; AcOH / dimethylsulfoxide

With piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; Dess-Martin periodane; acetic acid; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(03)00379-X