Technology Process of 4-benzyl-2-methoxy-3-pivaloylaminopyridine
There total 4 articles about 4-benzyl-2-methoxy-3-pivaloylaminopyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
N-(2-methoxy-3-pyridyl)-2,2-dimethylpropanamide;
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine;
In
tetrahydrofuran; hexane;
at -78 - -10 ℃;
for 2h;
benzyl bromide;
In
tetrahydrofuran; hexane;
at -78 - 20 ℃;
for 14.5h;
DOI:10.1016/S0040-4020(97)00771-0
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: NEt3 / CH2Cl2 / 0 - 20 °C
2.1: TMEDA; n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - -10 °C
2.2: 68 percent / tetrahydrofuran; hexane / 14.5 h / -78 - 20 °C
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine; triethylamine;
In
tetrahydrofuran; hexane; dichloromethane;
1.1: Acylation / 2.1: Metallation / 2.2: Alkylation;
DOI:10.1016/S0040-4020(97)00771-0
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 1.00 g / methanol / 8 h / 20 °C
2.1: 99 percent / hydrogen / palladized charcoal / methanol; tetrahydrofuran / 1 h / 20 °C
3.1: NEt3 / CH2Cl2 / 0 - 20 °C
4.1: TMEDA; n-butyllithium / tetrahydrofuran; hexane / 2 h / -78 - -10 °C
4.2: 68 percent / tetrahydrofuran; hexane / 14.5 h / -78 - 20 °C
With
n-butyllithium; N,N,N,N,-tetramethylethylenediamine; hydrogen; triethylamine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; hexane; dichloromethane;
1.1: Substitution / 2.1: Hydrogenation / 3.1: Acylation / 4.1: Metallation / 4.2: Alkylation;
DOI:10.1016/S0040-4020(97)00771-0
