4-(2,4-difluorophenyl)-piperazine-1-carboxylic acid 4-nitrophenyl ester

Base Information

• Chemical Name: 4-(2,4-difluorophenyl)-piperazine-1-carboxylic acid 4-nitrophenyl ester
• CAS No.: 1159598-37-4
• Molecular Formula: C₁₇H₁₅F₂N₃O₄
• Molecular Weight: 363.321
• Mol file: 1159598-37-4.mol

Synonyms:4-(2,4-difluorophenyl)-piperazine-1-carboxylic acid 4-nitrophenyl ester

Chemical Property of 4-(2,4-difluorophenyl)-piperazine-1-carboxylic acid 4-nitrophenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 4-(2,4-difluorophenyl)-piperazine-1-carboxylic acid 4-nitrophenyl ester

There total 1 articles about 4-(2,4-difluorophenyl)-piperazine-1-carboxylic acid 4-nitrophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

4-Nitrophenyl chloroformate (7693-46-1) + 1-(2,4-difluoro-phenyl)piperazine (115761-79-0) → 4-(2,4-difluorophenyl)-piperazine-1-carboxylic acid 4-nitrophenyl ester (1159598-37-4)

Guidance literature:

With triethylamine; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 100.0%

4-(2,4-difluorophenyl)-piperazine-1-carboxylic acid 4-nitrophenyl ester (1159598-37-4) + tert-butyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate (135065-76-8) → (2S)-[4-(2,4-difluoro-phenyl)-piperazine-1-carbonyloxymethyl]-morpholine-4-carboxylic acid tert-butyl ester (1159598-94-3)

Guidance literature:

tert-butyl (2S)-2-(hydroxymethyl)morpholine-4-carboxylate; With sodium hydride; In tetrahydrofuran; for 0.5h;

4-(2,4-difluorophenyl)-piperazine-1-carboxylic acid 4-nitrophenyl ester; In tetrahydrofuran; at 20 ℃; for 24h;

Reference yield: 86.0%

4-(2,4-difluorophenyl)-piperazine-1-carboxylic acid 4-nitrophenyl ester (1159598-37-4) + (R)-2-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester (135065-71-3) → (2R)-[4-(2,4-difluoro-phenyl)-piperazine-1-carbonyloxymethyl]-morpholine-4-carboxylic acid tert-butyl ester (1159598-97-6)

Guidance literature:

(R)-2-hydroxymethylmorpholine-4-carboxylic acid tert-butyl ester; With sodium hydride; In tetrahydrofuran; for 0.5h;

4-(2,4-difluorophenyl)-piperazine-1-carboxylic acid 4-nitrophenyl ester; In tetrahydrofuran; at 20 ℃; for 24h;

upstream raw materials:

4-Nitrophenyl chloroformate

1-(2,4-difluoro-phenyl)piperazine

Downstream raw materials:

3-[4-(2,4-difluoro-phenyl)-piperazine-1-carbonyloxymethyl]-morpholine-4-carboxylic acid tert-butyl ester

(2R)-[4-(2,4-difluoro-phenyl)-piperazine-1-carbonyloxymethyl]-morpholine-4-carboxylic acid tert-butyl ester

(2S)-[4-(2,4-difluoro-phenyl)-piperazine-1-carbonyloxymethyl]-morpholine-4-carboxylic acid tert-butyl ester

(4-methylmorpholin-3-yl)methyl 4-(2,4-difluorophenyl)piperazine-1-carboxylate