ethyl 4-[1-tert-butoxycarbonyl-(5S)-hydroxymethyl-(2S)-pyrrolidinylmethoxy]benzoate

Base Information

Chemical Name:ethyl 4-[1-tert-butoxycarbonyl-(5S)-hydroxymethyl-(2S)-pyrrolidinylmethoxy]benzoate
CAS No.:1416961-18-6
Molecular Formula:C₂₀H₂₉NO₆
Molecular Weight:379.453
Hs Code.:

Synonyms:ethyl 4-[1-tert-butoxycarbonyl-(5S)-hydroxymethyl-(2S)-pyrrolidinylmethoxy]benzoate

Suppliers and Price of ethyl 4-[1-tert-butoxycarbonyl-(5S)-hydroxymethyl-(2S)-pyrrolidinylmethoxy]benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl 4-[1-tert-butoxycarbonyl-(5S)-hydroxymethyl-(2S)-pyrrolidinylmethoxy]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl 4-[1-tert-butoxycarbonyl-(5S)-hydroxymethyl-(2S)-pyrrolidinylmethoxy]benzoate

There total 1 articles about ethyl 4-[1-tert-butoxycarbonyl-(5S)-hydroxymethyl-(2S)-pyrrolidinylmethoxy]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1416961-17-5
ethyl 4-[(5S)-benzyloxymethyl-1-tert-butoxycarbonyl-(2S)-pyrrolidinylmethoxy]benzoate

: 1416961-18-6
ethyl 4-[1-tert-butoxycarbonyl-(5S)-hydroxymethyl-(2S)-pyrrolidinylmethoxy]benzoate

Guidance literature:: With hydrogen; palladium(II) hydroxide; In ethanol; acetic acid; at 20 ℃; for 120h;
DOI:10.1016/j.bmc.2012.11.003

Reference yield:

: 1416961-18-6
ethyl 4-[1-tert-butoxycarbonyl-(5S)-hydroxymethyl-(2S)-pyrrolidinylmethoxy]benzoate

: C₁₅H₂₁NO₄

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 0.666667h;
DOI:10.1016/j.bmc.2012.11.003

Reference yield:

: 1416961-18-6
ethyl 4-[1-tert-butoxycarbonyl-(5S)-hydroxymethyl-(2S)-pyrrolidinylmethoxy]benzoate

: 877664-97-6
ethyl trans-4-[(5S)-[methoxy(methyl)amino]methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 10 steps

1: trifluoroacetic acid / dichloromethane / 0.67 h / 0 - 20 °C

2: Rh/Al₂O₃; trifluoroacetic acid; hydrogen / acetic acid; ethanol / 20 °C / 10?atm

3: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

4: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 °C

5: sodium hydride / N,N-dimethyl-formamide; ethanol / 0.67 h / 0 °C

6: potassium carbonate / water / 0.5 h / 70 °C

7: hydrogen; palladium(II) hydroxide / acetic acid; ethanol / 20 °C / 1?atm

8: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.5 h / 0 - 20 °C

9: sodium tris(acetoxy)borohydride / tetrahydrofuran / 2.5 h / 20 °C

10: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; Rh/Al₂O₃; hydrogen; palladium(II) hydroxide; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.11.003