1-Pyrrolidinecarboxylic acid, 2-[[[trans-4-(ethoxycarbonyl)cyclohexyl]oxy]methyl]-5-(4-morpholinylmeth yl)-, 1,1-dimethylethyl ester, (2S,5S)-

Base Information

Chemical Name:1-Pyrrolidinecarboxylic acid, 2-[[[trans-4-(ethoxycarbonyl)cyclohexyl]oxy]methyl]-5-(4-morpholinylmeth yl)-, 1,1-dimethylethyl ester, (2S,5S)-
CAS No.:877665-38-8
Molecular Formula:C24H42N2O6
Molecular Weight:454.607
Hs Code.:

1-Pyrrolidinecarboxylic acid,
2-[[[trans-4-(ethoxycarbonyl)cyclohexyl]oxy]methyl]-5-(4-morpholinylmeth
yl)-, 1,1-dimethylethyl ester, (2S,5S)-

Synonyms:

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Chemical Property of 1-Pyrrolidinecarboxylic acid, 2-[[[trans-4-(ethoxycarbonyl)cyclohexyl]oxy]methyl]-5-(4-morpholinylmeth yl)-, 1,1-dimethylethyl ester, (2S,5S)-

Chemical Property:

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Technology Process of 1-Pyrrolidinecarboxylic acid, 2-[[[trans-4-(ethoxycarbonyl)cyclohexyl]oxy]methyl]-5-(4-morpholinylmeth yl)-, 1,1-dimethylethyl ester, (2S,5S)-

There total 11 articles about 1-Pyrrolidinecarboxylic acid, 2-[[[trans-4-(ethoxycarbonyl)cyclohexyl]oxy]methyl]-5-(4-morpholinylmeth yl)-, 1,1-dimethylethyl ester, (2S,5S)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 877664-92-1
ehyl trans-4-[1-tert-butoxycarbonyl-(5S)-formyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

: 877665-38-8
ethyl trans-4-[1-tert-butoxycarbonyl-(5S)-(4-morpholinyl)methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Guidance literature:: With sodium tris(acetoxy)borohydride; In tetrahydrofuran; at 20 ℃; for 2.5h;
DOI:10.1016/j.bmc.2012.11.003

Reference yield:

: 1416961-17-5
ethyl 4-[(5S)-benzyloxymethyl-1-tert-butoxycarbonyl-(2S)-pyrrolidinylmethoxy]benzoate

: 877665-38-8
ethyl trans-4-[1-tert-butoxycarbonyl-(5S)-(4-morpholinyl)methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 10 steps

1: hydrogen; palladium(II) hydroxide / acetic acid; ethanol / 120 h / 20 °C / 1?atm

2: trifluoroacetic acid / dichloromethane / 0.67 h / 0 - 20 °C

3: Rh/Al₂O₃; trifluoroacetic acid; hydrogen / acetic acid; ethanol / 20 °C / 10?atm

4: triethylamine / dichloromethane / 2.5 h / 0 - 20 °C

5: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 °C

6: sodium hydride / N,N-dimethyl-formamide; ethanol / 0.67 h / 0 °C

7: potassium carbonate / water / 0.5 h / 70 °C

8: hydrogen; palladium(II) hydroxide / acetic acid; ethanol / 20 °C / 1?atm

9: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.5 h / 0 - 20 °C

10: sodium tris(acetoxy)borohydride / tetrahydrofuran / 2.5 h / 20 °C

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; Rh/Al₂O₃; hydrogen; palladium(II) hydroxide; sodium tris(acetoxy)borohydride; sodium hydride; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2012.11.003

Reference yield:

: 1416961-30-2
ethyl trans-4-[1-tert-butoxycarbonyl-(5S)-benzyloxymethyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

: 877665-38-8
ethyl trans-4-[1-tert-butoxycarbonyl-(5S)-(4-morpholinyl)methyl-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium(II) hydroxide / acetic acid; ethanol / 20 °C / 1?atm

2: trichloroisocyanuric acid; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical / dichloromethane / 0.5 h / 0 - 20 °C

3: sodium tris(acetoxy)borohydride / tetrahydrofuran / 2.5 h / 20 °C

With 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; trichloroisocyanuric acid; hydrogen; palladium(II) hydroxide; sodium tris(acetoxy)borohydride; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1016/j.bmc.2012.11.003