N-bytyl-6-(3-chlorobenzyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

Base Information

Chemical Name:N-bytyl-6-(3-chlorobenzyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide
CAS No.:1283600-83-8
Molecular Formula:C₂₆H₂₅ClN₂O₂
Molecular Weight:432.95
Hs Code.:

Synonyms:N-bytyl-6-(3-chlorobenzyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

Suppliers and Price of N-bytyl-6-(3-chlorobenzyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-bytyl-6-(3-chlorobenzyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-bytyl-6-(3-chlorobenzyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

There total 4 articles about N-bytyl-6-(3-chlorobenzyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 2769-64-4
n-butyl isonitrile

: 6720-26-9
2-(2-formyl-phenyl)-benzoic acid

: 4152-90-3
m-chlorobenzylamine

: 1283600-83-8
N-bytyl-6-(3-chlorobenzyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

Guidance literature:: With sodium sulfate; In 2,2,2-trifluoroethanol; at 110 ℃; for 0.833333h; Sealed; Inert atmosphere; Irradiation;
DOI:10.1021/jo200251q

Reference yield:

: 610-94-6
2-bromobenzoic acid methyl ester

: 1283600-83-8
N-bytyl-6-(3-chlorobenzyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / 1,4-dioxane; water / 0.42 h / 120 °C / Sealed; Irradiation

2.1: water; lithium hydroxide / tetrahydrofuran / 40 °C

2.2: pH 7

3.1: sodium sulfate / 2,2,2-trifluoroethanol / 0.83 h / 110 °C / Sealed; Inert atmosphere; Irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; water; sodium carbonate; sodium sulfate; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; 2,2,2-trifluoroethanol; water; 1.1: Suzuki-Miyaura cross-coupling / 3.1: Ugi 4CR reaction;
DOI:10.1021/jo200251q

Reference yield:

: 16231-67-7
methyl 2'-formyl-[1,1'-biphenyl]-2-carboxylate

: 1283600-83-8
N-bytyl-6-(3-chlorobenzyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 40 °C

1.2: pH 7

2.1: sodium sulfate / 2,2,2-trifluoroethanol / 0.83 h / 110 °C / Sealed; Inert atmosphere; Irradiation

With water; sodium sulfate; lithium hydroxide; In tetrahydrofuran; 2,2,2-trifluoroethanol; 2.1: Ugi 4CR reaction;
DOI:10.1021/jo200251q