methyl 2-(2-formylphenyl)benzoate

Base Information

• Chemical Name: methyl 2-(2-formylphenyl)benzoate
• CAS No.: 16231-67-7
• Molecular Formula: C15H12 O3
• Molecular Weight: 240.258
• Hs Code.: 2918300090
• Mol file: 16231-67-7.mol

Synonyms:Diphenaldehydicacid, methyl ester (6CI,8CI); Methyl 2-formyl-2'-biphenylcarboxylate; Methyl2'-formylbiphenyl-2-carboxylate; NSC 314067

Chemical Property of methyl 2-(2-formylphenyl)benzoate

Chemical Property:

• Vapor Pressure: 4.77E-07mmHg at 25°C
• Boiling Point: 413.5°Cat760mmHg
• Flash Point: 185.4°C
• PSA: 43.37000
• Density: 1.176g/cm³
• LogP: 2.95270

Purity/Quality:

99% ^*data from raw suppliers

Methyl2'-formyl-[1,1'-biphenyl]-2-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 2-(2-formylphenyl)benzoate

There total 11 articles about methyl 2-(2-formylphenyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2'-Hydroxymethyl-1,1'-biphenyl-carbonsaeuremethylester (38399-64-3) → methyl 2'-formyl-[1,1'-biphenyl]-2-carboxylate (16231-67-7)

Guidance literature:

With manganese(IV) oxide; In chloroform; for 2h; Heating;

Reference yield: 88.0%

o-iodo-methyl-benzoic acid (610-97-9) + 2-formylbenzene boronic acid (40138-16-7) → methyl 2'-formyl-[1,1'-biphenyl]-2-carboxylate (16231-67-7)

Guidance literature:

With palladium diacetate; triphenylphosphine; cesium fluoride; In N,N-dimethyl-formamide; at 100 ℃; for 72h;

DOI:10.1039/c0ob00977f

Reference yield: 84.0%

2-bromobenzoic acid methyl ester (610-94-6) + 2-formylbenzene boronic acid (40138-16-7) → methyl 2'-formyl-[1,1'-biphenyl]-2-carboxylate (16231-67-7)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 120 ℃; for 0.416667h; Sealed; Irradiation;

DOI:10.1021/jo200251q

upstream raw materials:

methanol

5,8-Dimethoxy-5,8-dihydro-dibenzo[d,f][1,2]dioxocin

2'-Hydroxymethyl-1,1'-biphenyl-carbonsaeuremethylester

2-Iodobenzoic acid

Downstream raw materials:

N-cyclohexyl-6-(4-methoxybenzyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

N-tert-butyl-6-cyclohexyl-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

6-(4-methoxybenzyl)-N-(4-methoxyphenyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

N-tert-butyl-6-(4-hydroxyphenethyl)-7-oxo-6,7-dihydro-5H-dibenzo[c,e]azepine-5-carboxamide

Refernces

• 1、 Edwards, David J.,House, David,Sheldrake, Helen M.,Stone, Susan J.,Wallace, Timothy W.. "Kinetic and thermodynamic control of axial chirality in biaryl-derived fused oxazolidine lactams exploiting a centre-axis relay of unit efficiency". . p. 2658 - 2669. Retrieved 2007.
• 2、 Knowles, Jonathan P.,O'Connor, Victoria E.,Whiting, Andrew. "Studies towards the synthesis of the northern polyene of viridenomycin and synthesis of Z-double bond analogues". experimental part. p. 1876 - 1886. Retrieved 2011/04/25.