methyl 3-(2-{[(3-cyano-4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-4-oxo-1,4-dihydro-5-pyrimidinyl)propanoate

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Chemical Name:methyl 3-(2-{[(3-cyano-4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-4-oxo-1,4-dihydro-5-pyrimidinyl)propanoate
CAS No.:1380427-94-0
Molecular Formula:C₂₃H₁₈F₃N₃O₄S
Molecular Weight:489.475
Hs Code.:

Synonyms:methyl 3-(2-{[(3-cyano-4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-4-oxo-1,4-dihydro-5-pyrimidinyl)propanoate

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Chemical Property of methyl 3-(2-{[(3-cyano-4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-4-oxo-1,4-dihydro-5-pyrimidinyl)propanoate

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Technology Process of methyl 3-(2-{[(3-cyano-4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-4-oxo-1,4-dihydro-5-pyrimidinyl)propanoate

There total 5 articles about methyl 3-(2-{[(3-cyano-4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-4-oxo-1,4-dihydro-5-pyrimidinyl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 9.34%

: 1369254-63-6
5-(chloromethyl)-2-{[3-(trifluoromethyl)phenyl]oxy}benzonitrile

: 1380429-71-9
methyl 3-(4-oxo-2-thioxo-1,2,3,4-tetrahydro-5-pyrimidinyl)propanoate

: 1380427-94-0
methyl 3-(2-{[(3-cyano-4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-4-oxo-1,4-dihydro-5-pyrimidinyl)propanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,2-dichloro-ethane; at 80 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 218301-22-5
2-fluoro-5-formylbenzonitrile

: 1380427-94-0
methyl 3-(2-{[(3-cyano-4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-4-oxo-1,4-dihydro-5-pyrimidinyl)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / dimethyl sulfoxide / 100 °C

2: sodium tetrahydroborate; ethanol / 3 h / 20 °C

3: thionyl chloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 0.5 h / 80 °C / Microwave irradiation

With sodium tetrahydroborate; thionyl chloride; ethanol; potassium carbonate; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide; 1,2-dichloro-ethane;

Reference yield:

: 1369254-61-4
5-formyl-2-{[3-(trifluoromethyl)phenyl]oxy}benzonitrile

: 1380427-94-0
methyl 3-(2-{[(3-cyano-4-{[3-(trifluoromethyl)phenyl]oxy}phenyl)methyl]thio}-4-oxo-1,4-dihydro-5-pyrimidinyl)propanoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate; ethanol / 3 h / 20 °C

2: thionyl chloride / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: N-ethyl-N,N-diisopropylamine / 1,2-dichloro-ethane / 0.5 h / 80 °C / Microwave irradiation

With sodium tetrahydroborate; thionyl chloride; ethanol; N-ethyl-N,N-diisopropylamine; In dichloromethane; 1,2-dichloro-ethane;