(2S)-2,3-dihydroxypropyl trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate

Base Information

Chemical Name:(2S)-2,3-dihydroxypropyl trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate
CAS No.:1609976-85-3
Molecular Formula:C₂₉H₃₄F₂N₄O₅
Molecular Weight:556.61
Hs Code.:

(2S)-2,3-dihydroxypropyl trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate

Synonyms:(2S)-2,3-dihydroxypropyl trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate

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Chemical Property of (2S)-2,3-dihydroxypropyl trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate

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Technology Process of (2S)-2,3-dihydroxypropyl trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate

There total 11 articles about (2S)-2,3-dihydroxypropyl trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1609976-99-9
[(4S)-2,2-dimethyl-1,3-dioxolan-4-yl]methyl trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate

: 1609976-85-3
(2S)-2,3-dihydroxypropyl trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate

Guidance literature:: With water; trifluoroacetic acid; at 20 ℃; for 1h;

Reference yield:

: 32529-80-9,36218-60-7
trans-1-chlorocarbonyl-4-(methoxycarbonyl)-cyclohexane

: 1609976-85-3
(2S)-2,3-dihydroxypropyl trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / toluene / 3 h / 15 - 20 °C / Cooling with ice

2.1: isopropylmagnesium chloride / tetrahydrofuran; dichloromethane / 0.67 h / 0 - 5 °C

2.2: 2.25 h / 0 °C

2.3: 0 - 20 °C

3.1: ChiralPak AD-10 urn, 300x50 mm ID / ethanol / Resolution of racemate

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

4.2: 2.5 h / 90 °C / Inert atmosphere

5.1: sodium hydroxide; water / methanol / 1 h / 65 °C

5.2: 1.5 h / 50 °C

6.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran; N,N-dimethyl acetamide / 18 h

7.1: water; trifluoroacetic acid / 1 h / 20 °C

With dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; isopropylmagnesium chloride; potassium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; bis(pinacol)diborane; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; N,N-dimethyl acetamide; toluene;

Reference yield:

: 1411772-54-7
methyl trans-4-[(1R)-1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate

: 1609976-85-3
(2S)-2,3-dihydroxypropyl trans-4-[(1R)-1-(6-{[4-(difluoromethyl)pyridin-2-yl]amino}-4-methyl-2,3'-bipyridin-6'-yl)-1-hydroxyethyl]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; bis(pinacol)diborane / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

1.2: 2.5 h / 90 °C / Inert atmosphere

2.1: sodium hydroxide; water / methanol / 1 h / 65 °C

2.2: 1.5 h / 50 °C

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / tetrahydrofuran; N,N-dimethyl acetamide / 18 h

4.1: water; trifluoroacetic acid / 1 h / 20 °C

With dmap; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; water; potassium acetate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; bis(pinacol)diborane; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl acetamide;