methyl trans-4-[(1R)-1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate

Base Information

Chemical Name:methyl trans-4-[(1R)-1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate
CAS No.:1411772-54-7
Molecular Formula:C₁₅H₂₀BrNO₃
Molecular Weight:342.233
Hs Code.:

Synonyms:methyl trans-4-[(1R)-1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate

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Chemical Property of methyl trans-4-[(1R)-1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate

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Technology Process of methyl trans-4-[(1R)-1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate

There total 6 articles about methyl trans-4-[(1R)-1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1411772-44-5
methyl trans-4-[1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate

: 1411772-55-8
methyl trans-4-[(1S)-1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate

: 1411772-54-7
methyl trans-4-[(1R)-1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate

Guidance literature:: With ChiralPak AD; In ethanol; carbon dioxide; Resolution of racemate;

Reference yield:

: 183996-94-3
trans-4-acetylcyclohexanecarboxylic acid methyl ester

: 1411772-55-8
methyl trans-4-[(1S)-1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate

: 1411772-54-7
methyl trans-4-[(1R)-1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: TurboGrignard / tetrahydrofuran / 1.25 h / -5 - 0 °C

1.2: 1 h / 0 °C

1.3: 15 h / 0 - 20 °C

2.1: ChiralPak AD / ethanol; carbon dioxide / Resolution of racemate

With TurboGrignard; In tetrahydrofuran; ethanol; carbon dioxide;

Reference yield:

: 223463-13-6
2-iodo-5-bromopyridine

: 1411772-55-8
methyl trans-4-[(1S)-1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate

: 1411772-54-7
methyl trans-4-[(1R)-1-(5-bromopyridin-2-yl)-1-hydroxyethyl]cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: TurboGrignard / tetrahydrofuran / 1.25 h / -5 - 0 °C

1.2: 1 h / 0 °C

1.3: 15 h / 0 - 20 °C

2.1: ChiralPak AD / ethanol; carbon dioxide / Resolution of racemate

With TurboGrignard; In tetrahydrofuran; ethanol; carbon dioxide;