(2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)amine

Base Information

Chemical Name:(2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)amine
CAS No.:1262786-72-0
Molecular Formula:C₂₄H₃₇N₅
Molecular Weight:395.591
Hs Code.:

Synonyms:(2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)amine

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Chemical Property of (2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)amine

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Technology Process of (2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)amine

There total 3 articles about (2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1282658-40-5
C₂₄H₃₃N₅

: 1262786-72-0
(2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)amine

Guidance literature:: With ammonium hydroxide; hydrogen; In ethanol; at 50 ℃; for 18h; under 2585.81 Torr;
DOI:10.1016/j.bmcl.2011.01.030

Reference yield:

: 31004-60-1
3-cyano-3-phenyl-1-butanal

: 1262786-72-0
(2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)amine

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C

2: ammonium hydroxide; hydrogen / ethanol / 18 h / 50 °C / 2585.81 Torr

With ammonium hydroxide; hydrogen; sodium tris(acetoxy)borohydride; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.01.030

Reference yield:

: 123064-05-1
3-cyano-3-methyl-3-phenylpropanoic acid ethyl ester

: 1262786-72-0
(2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)amine

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C

2: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C

3: ammonium hydroxide; hydrogen / ethanol / 18 h / 50 °C / 2585.81 Torr

With ammonium hydroxide; hydrogen; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.01.030