4,4-difluoro-N-(2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)cyclohexanecarboxamide

Base Information

Chemical Name:4,4-difluoro-N-(2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)cyclohexanecarboxamide
CAS No.:1262786-48-0
Molecular Formula:C₃₁H₄₅F₂N₅O
Molecular Weight:541.728
Hs Code.:

4,4-difluoro-N-(2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)cyclohexanecarboxamide

Synonyms:

Suppliers and Price of 4,4-difluoro-N-(2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)cyclohexanecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4,4-difluoro-N-(2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)cyclohexanecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4,4-difluoro-N-(2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)cyclohexanecarboxamide

There total 5 articles about 4,4-difluoro-N-(2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)cyclohexanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122665-97-8
4,4-difluorocyclohexanecarboxylic acid

: 1262786-72-0
(2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)amine

: 1262786-48-0
4,4-difluoro-N-(2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)cyclohexanecarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; at 20 ℃; for 18h;
DOI:10.1016/j.bmcl.2011.01.030

Reference yield:

: 1282658-40-5
C₂₄H₃₃N₅

: 1262786-48-0
4,4-difluoro-N-(2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: ammonium hydroxide; hydrogen / ethanol / 18 h / 50 °C / 2585.81 Torr

2: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 18 h / 20 °C

With ammonium hydroxide; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.01.030

Reference yield:

: 123064-05-1
3-cyano-3-methyl-3-phenylpropanoic acid ethyl ester

: 1262786-48-0
4,4-difluoro-N-(2-methyl-4-{(1R,5S)-3-[3-methyl-5-(1-methylethyl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl}-2-phenylbutyl)cyclohexanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: diisobutylaluminium hydride / tetrahydrofuran / 1 h / -78 °C

2: sodium tris(acetoxy)borohydride / dichloromethane / 18 h / 20 °C

3: ammonium hydroxide; hydrogen / ethanol / 18 h / 50 °C / 2585.81 Torr

4: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 18 h / 20 °C

With ammonium hydroxide; hydrogen; sodium tris(acetoxy)borohydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2011.01.030