t-butyl N-4-[2-{1-(4-chlorobenzoyl)-5-methoxy-2′-trifluoromethyl-1H-indol-3-yl}acetamido]butyl carbamate

Base Information

• Chemical Name: t-butyl N-4-[2-{1-(4-chlorobenzoyl)-5-methoxy-2′-trifluoromethyl-1H-indol-3-yl}acetamido]butyl carbamate
• CAS No.: 1537876-07-5
• Molecular Formula: C₂₈H₃₁ClF₃N₃O₅
• Molecular Weight: 582.019
• Mol file: 1537876-07-5.mol

Synonyms:t-butyl N-4-[2-{1-(4-chlorobenzoyl)-5-methoxy-2′-trifluoromethyl-1H-indol-3-yl}acetamido]butyl carbamate

Chemical Property of t-butyl N-4-[2-{1-(4-chlorobenzoyl)-5-methoxy-2′-trifluoromethyl-1H-indol-3-yl}acetamido]butyl carbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of t-butyl N-4-[2-{1-(4-chlorobenzoyl)-5-methoxy-2′-trifluoromethyl-1H-indol-3-yl}acetamido]butyl carbamate

There total 1 articles about t-butyl N-4-[2-{1-(4-chlorobenzoyl)-5-methoxy-2′-trifluoromethyl-1H-indol-3-yl}acetamido]butyl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-amino-4-[(tert-butyloxycarbonyl)amino]butane (68076-36-8) + CF3-indomethacin (1428734-36-4) → t-butyl N-4-[2-{1-(4-chlorobenzoyl)-5-methoxy-2′-trifluoromethyl-1H-indol-3-yl}acetamido]butyl carbamate (1537876-07-5)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 25 ℃; for 16h;

DOI:10.1021/ml400485g

Reference yield: 98.0%

t-butyl N-4-[2-{1-(4-chlorobenzoyl)-5-methoxy-2′-trifluoromethyl-1H-indol-3-yl}acetamido]butyl carbamate (1537876-07-5) → N-(4-aminobutyl)-2-{1-(4-chlorobenzoyl)-5-methoxy-2′-trifluoromethyl-1H-indol-3-yl}acetamide hydrochloride (1537876-08-6)

Guidance literature:

With hydrogenchloride; In dichloromethane; at 25 ℃; for 1h;

DOI:10.1021/ml400485g

upstream raw materials:

1-amino-4-[(tert-butyloxycarbonyl)amino]butane

CF₃-indomethacin

Downstream raw materials:

N-(4-aminobutyl)-2-{1-(4-chlorobenzoyl)-5-methoxy-2′-trifluoromethyl-1H-indol-3-yl}acetamide hydrochloride