(1R,3S)-2-benzyl 3-methyl 1-(2-methoxycarbonylethyl)-9-methyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-2,3-dicarboxylate

Base Information

Chemical Name:(1R,3S)-2-benzyl 3-methyl 1-(2-methoxycarbonylethyl)-9-methyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-2,3-dicarboxylate
CAS No.:136612-35-6
Molecular Formula:C₂₆H₂₈N₂O₆
Molecular Weight:464.518
Hs Code.:

Synonyms:(1R,3S)-2-benzyl 3-methyl 1-(2-methoxycarbonylethyl)-9-methyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-2,3-dicarboxylate

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Chemical Property of (1R,3S)-2-benzyl 3-methyl 1-(2-methoxycarbonylethyl)-9-methyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-2,3-dicarboxylate

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Technology Process of (1R,3S)-2-benzyl 3-methyl 1-(2-methoxycarbonylethyl)-9-methyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-2,3-dicarboxylate

There total 6 articles about (1R,3S)-2-benzyl 3-methyl 1-(2-methoxycarbonylethyl)-9-methyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-2,3-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 136612-33-4
(1R,3S)-2-benzyl 3-methyl 1-(2-methoxycarbonylethyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-2,3-dicarboxylate

: 74-88-4
methyl iodide

: 136612-35-6
(1R,3S)-2-benzyl 3-methyl 1-(2-methoxycarbonylethyl)-9-methyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-2,3-dicarboxylate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃;
DOI:10.1016/S0040-4039(00)79407-X

Reference yield:

: 126366-08-3,136612-30-1
(3S)-methyl 1-(2-methoxycarbonylethyl)-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-3-carboxylate

: 136612-35-6
(1R,3S)-2-benzyl 3-methyl 1-(2-methoxycarbonylethyl)-9-methyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-2,3-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 15 percent / NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

2: 63 percent / NaH / dimethylformamide / 1) 0 deg C, 1 h, 2) RT, 30 min

With sodium hydride; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 4-[(E)-(S)-2-(1H-Indol-3-yl)-1-methoxycarbonyl-ethylimino]-butyric acid methyl ester

: 136612-35-6
(1R,3S)-2-benzyl 3-methyl 1-(2-methoxycarbonylethyl)-9-methyl-1,2,3,4-tetrahydro-9H-pyrido<3,4-b>indole-2,3-dicarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: TFA / CH₂Cl₂ / 2 h / 0 °C

2: 15 percent / NaHCO₃ / CH₂Cl₂ / 4 h / Ambient temperature

3: 63 percent / NaH / dimethylformamide / 1) 0 deg C, 1 h, 2) RT, 30 min

With sodium hydride; sodium hydrogencarbonate; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;