(S)-2-(3-((3,4-difluorophenyl)carbamoyl)-4-fluorophenylsulfonamido)propanoic acid

Base Information

Chemical Name:(S)-2-(3-((3,4-difluorophenyl)carbamoyl)-4-fluorophenylsulfonamido)propanoic acid
CAS No.:1616809-05-2
Molecular Formula:C₁₆H₁₃F₃N₂O₅S
Molecular Weight:402.351
Hs Code.:

Synonyms:(S)-2-(3-((3,4-difluorophenyl)carbamoyl)-4-fluorophenylsulfonamido)propanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(3-((3,4-difluorophenyl)carbamoyl)-4-fluorophenylsulfonamido)propanoic acid

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Technology Process of (S)-2-(3-((3,4-difluorophenyl)carbamoyl)-4-fluorophenylsulfonamido)propanoic acid

There total 3 articles about (S)-2-(3-((3,4-difluorophenyl)carbamoyl)-4-fluorophenylsulfonamido)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 39.0%

: 56-41-7,25191-17-7,18875-37-1
L-alanin

: 1616809-39-2
3-((3,4-difluorophenyl)carbamoyl)-4-fluorobenzene-1-sulfonyl chloride

: 1616809-05-2
(S)-2-(3-((3,4-difluorophenyl)carbamoyl)-4-fluorophenylsulfonamido)propanoic acid

Guidance literature:: With N-ethyl-N,N-diisopropylamine; sodium hydroxide; In acetone; at 0 - 20 ℃; for 16.25h;

Reference yield:

: 949485-81-8
5-(chlorosulfonyl)-2-fluorobenzoyl chloride

: 1616809-05-2
(S)-2-(3-((3,4-difluorophenyl)carbamoyl)-4-fluorophenylsulfonamido)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 16 h

2: N-ethyl-N,N-diisopropylamine; sodium hydroxide / acetone / 16.25 h / 0 - 20 °C

With N-ethyl-N,N-diisopropylamine; sodium hydroxide; In acetone; toluene;

Reference yield:

: 37098-75-2
2-fluoro-5-chlorosulfonylbenzoic acid

: 1616809-05-2
(S)-2-(3-((3,4-difluorophenyl)carbamoyl)-4-fluorophenylsulfonamido)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / 1,2-dichloro-ethane / 1 h / Reflux

2: toluene / 16 h

3: N-ethyl-N,N-diisopropylamine; sodium hydroxide / acetone / 16.25 h / 0 - 20 °C

With thionyl chloride; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In 1,2-dichloro-ethane; acetone; toluene;