trans-4-(4-{3-[(1S)-1-(2-Chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3,5-dimethyl-1H-pyrazol-1-yl)cyclohexanol

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Chemical Name:trans-4-(4-{3-[(1S)-1-(2-Chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3,5-dimethyl-1H-pyrazol-1-yl)cyclohexanol
CAS No.:1350322-63-2
Molecular Formula:C₂₇H₃₀ClFN₄O₂
Molecular Weight:497.012
Hs Code.:

Synonyms:trans-4-(4-{3-[(1S)-1-(2-Chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3,5-dimethyl-1H-pyrazol-1-yl)cyclohexanol

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Chemical Property of trans-4-(4-{3-[(1S)-1-(2-Chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3,5-dimethyl-1H-pyrazol-1-yl)cyclohexanol

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Technology Process of trans-4-(4-{3-[(1S)-1-(2-Chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3,5-dimethyl-1H-pyrazol-1-yl)cyclohexanol

There total 13 articles about trans-4-(4-{3-[(1S)-1-(2-Chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3,5-dimethyl-1H-pyrazol-1-yl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₃₃H₄₄ClFN₄O₂Si

: 1350322-63-2
trans-4-(4-{3-[(1S)-1-(2-Chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3,5-dimethyl-1H-pyrazol-1-yl)cyclohexanol

Guidance literature:: With hydrogenchloride; water; In 1,4-dioxane; at 20 ℃; for 1h;

Reference yield:

: 23511-05-9
toluene-4-sulfonic acid 1,4-dioxa-spiro[4.5]dec-8-yl ester

: 1350322-63-2
trans-4-(4-{3-[(1S)-1-(2-Chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3,5-dimethyl-1H-pyrazol-1-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 50 °C

2.1: water; pyridinium p-toluenesulfonate / acetone / 60 °C

3.1: ethanol; sodium tetrahydroborate / 3 h / 20 °C

4.1: dmap; 1H-imidazole / dichloromethane / 0.33 h / 20 °C

5.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 80 °C

6.1: hydrogenchloride; water / 1,4-dioxane / 1 h / 20 °C

With 1H-imidazole; hydrogenchloride; dmap; sodium tetrahydroborate; ethanol; water; pyridinium p-toluenesulfonate; sodium hydride; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetone;

Reference yield:

: 2033-45-6
4-iodo-3,5-dimethyl-1H-pyrazole

: 1350322-63-2
trans-4-(4-{3-[(1S)-1-(2-Chloro-3-fluoro-6-methoxyphenyl)ethyl]-1H-pyrrolo[2,3-b]pyridin-5-yl}-3,5-dimethyl-1H-pyrazol-1-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 20 °C

1.2: 50 °C

2.1: water; pyridinium p-toluenesulfonate / acetone / 60 °C

3.1: ethanol; sodium tetrahydroborate / 3 h / 20 °C

4.1: dmap; 1H-imidazole / dichloromethane / 0.33 h / 20 °C

5.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 80 °C

6.1: hydrogenchloride; water / 1,4-dioxane / 1 h / 20 °C

With 1H-imidazole; hydrogenchloride; dmap; sodium tetrahydroborate; ethanol; water; pyridinium p-toluenesulfonate; sodium hydride; sodium hydrogencarbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetone;