7-benzylthio-3-(2-chlorophenyl)-3,4-dihydropyrimido[4,5-d]-pyrimidin-2(1H)-one

Base Information

• Chemical Name: 7-benzylthio-3-(2-chlorophenyl)-3,4-dihydropyrimido[4,5-d]-pyrimidin-2(1H)-one
• CAS No.: 335318-13-3
• Molecular Formula: C₁₉H₁₅ClN₄OS
• Molecular Weight: 382.873

Synonyms:7-benzylthio-3-(2-chlorophenyl)-3,4-dihydropyrimido[4,5-d]-pyrimidin-2(1H)-one

Chemical Property of 7-benzylthio-3-(2-chlorophenyl)-3,4-dihydropyrimido[4,5-d]-pyrimidin-2(1H)-one

Chemical Property:

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Technology Process of 7-benzylthio-3-(2-chlorophenyl)-3,4-dihydropyrimido[4,5-d]-pyrimidin-2(1H)-one

There total 2 articles about 7-benzylthio-3-(2-chlorophenyl)-3,4-dihydropyrimido[4,5-d]-pyrimidin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phosgene (75-44-5) + 5-(2-chlorophenyl)aminomethyl-4-amino-2-benzylthiopyrimidine (335318-30-4) → 7-benzylthio-3-(2-chlorophenyl)-3,4-dihydropyrimido[4,5-d]-pyrimidin-2(1H)-one (335318-13-3)

Guidance literature:

With triethylamine; In tetrahydrofuran; toluene; at -10 - 20 ℃;

Reference yield:

phosgene (75-44-5) + 4-amino-2-benzylsulfanyl-pyrimidine-5-carboxylate (335318-29-1) + 5-(2-chlorophenyl)aminomethyl-4-amino-2-benzylthiopyrimidine (335318-30-4) + p-toluenesulfonic acid monohydrate (6192-52-5) + o-chloroaniline (95-51-2) → 7-benzylthio-3-(2-chlorophenyl)-3,4-dihydropyrimido[4,5-d]-pyrimidin-2(1H)-one (335318-13-3)

Guidance literature:

With sodium hydroxide; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; toluene;

Reference yield: 88.0%

7-benzylthio-3-(2-chlorophenyl)-3,4-dihydropyrimido[4,5-d]-pyrimidin-2(1H)-one (335318-13-3) + 2-methylmercapto-ethanol (5271-38-5) → C22H21ClN4OS2

Guidance literature:

With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 18 - 25 ℃; for 96h;

upstream raw materials:

phosgene

5-(2-chlorophenyl)aminomethyl-4-amino-2-benzylthiopyrimidine

4-amino-2-benzylsulfanyl-pyrimidine-5-carboxylate

p-toluenesulfonic acid monohydrate

Downstream raw materials:

7-benzylthio-3-(2-chlorophenyl)-1-(ethoxycarbonylmethyl)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one

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