Technology Process of 2-allyl-4,6-dimethoxybenzoic acid
There total 2 articles about 2-allyl-4,6-dimethoxybenzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
[ruthenium(II)(η6-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]2; trifluoroacetic acid;
at 60 ℃;
for 24h;
regiospecific reaction;
Inert atmosphere;
Sealed tube;
DOI:10.1021/acs.orglett.8b01762
- Guidance literature:
-
2,4 dimethoxybenzoic acid;
With
N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium;
In
tetrahydrofuran;
at -90 ℃;
for 0.5h;
Inert atmosphere;
allyl bromide;
In
tetrahydrofuran;
at -80 ℃;
for 2h;
Inert atmosphere;
DOI:10.1080/00397911.2012.681827
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: 14.45 g / 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 24 h / 20 °C
2.1: 4-methylmorpholine N-oxide; H2O / OsO4 / tetrahydrofuran; 2-methyl-propan-2-ol / 24 h / 20 °C
3.1: 6.3 g / NaIO4 / methanol; H2O / 2 h / 20 °C
4.1: nBu2BOTf / toluene; CH2Cl2 / 0.08 h / -10 °C
4.2: iPr2NEt / toluene; CH2Cl2 / 2 h / 0 °C
4.3: 85 percent / toluene; CH2Cl2 / -78 - 0 °C
5.1: 95 percent / proton sponge / CH2Cl2 / -60 - 20 °C
6.1: 94 percent / NaBH4 / tetrahydrofuran; H2O / 73 h / 0 - 20 °C
7.1: 95 percent / Et3N; DMAP / CH2Cl2 / 24 h / 20 °C
8.1: 97 percent / sodium iodide; zinc / 1,2-dimethoxy-ethane / 4 h / Heating
With
dmap; sodium tetrahydroborate; sodium periodate; Proton Sponge; di-n-butylboryl trifluoromethanesulfonate; water; 4-methylmorpholine N-oxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; sodium iodide; zinc;
osmium(VIII) oxide;
In
tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; toluene; tert-butyl alcohol;
4.3: Evans aldol reaction;
DOI:10.1021/ol0629317
