6-(1-Hydroxy-1-methyl-ethyl)-2-trimethylsilanyl-cyclohex-1-enecarboxylic acid diisopropylamide

Base Information

Chemical Name:6-(1-Hydroxy-1-methyl-ethyl)-2-trimethylsilanyl-cyclohex-1-enecarboxylic acid diisopropylamide
CAS No.:80997-62-2
Molecular Formula:C₁₉H₃₇NO₂Si
Molecular Weight:339.594
Hs Code.:

Synonyms:6-(1-Hydroxy-1-methyl-ethyl)-2-trimethylsilanyl-cyclohex-1-enecarboxylic acid diisopropylamide

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Chemical Property of 6-(1-Hydroxy-1-methyl-ethyl)-2-trimethylsilanyl-cyclohex-1-enecarboxylic acid diisopropylamide

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Technology Process of 6-(1-Hydroxy-1-methyl-ethyl)-2-trimethylsilanyl-cyclohex-1-enecarboxylic acid diisopropylamide

There total 4 articles about 6-(1-Hydroxy-1-methyl-ethyl)-2-trimethylsilanyl-cyclohex-1-enecarboxylic acid diisopropylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 80997-59-7
N,N-diisopropyl-6-(trimethylsilyl)-1-cyclohexenecarboxamide

: 67-64-1
acetone

: 80997-62-2
6-(1-Hydroxy-1-methyl-ethyl)-2-trimethylsilanyl-cyclohex-1-enecarboxylic acid diisopropylamide

Guidance literature:: With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; 1.) -78 deg C; 2.) -78 deg C to RT;
DOI:10.1021/ja00302a024

Reference yield:

: 636-82-8
cyclohexene-1-carboxylic acid

: 80997-62-2
6-(1-Hydroxy-1-methyl-ethyl)-2-trimethylsilanyl-cyclohex-1-enecarboxylic acid diisopropylamide

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / 2.5 h / Heating

2: diethyl ether / 4 h / Ambient temperature

3: 57 percent / sec-BuLi, TMEDA / tetrahydrofuran / 1.) -78 deg C, 15 min; 2.) -78 deg C to RT

4: 73 percent / sec-BuLi, TMEDA / tetrahydrofuran / 1.) -78 deg C; 2.) -78 deg C to RT

With thionyl chloride; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ja00302a024

Reference yield:

: 80997-37-1
N,N-diisopropyl-1-cyclohexenecarboxamide

: 80997-62-2
6-(1-Hydroxy-1-methyl-ethyl)-2-trimethylsilanyl-cyclohex-1-enecarboxylic acid diisopropylamide

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / sec-BuLi, TMEDA / tetrahydrofuran / 1.) -78 deg C, 15 min; 2.) -78 deg C to RT

2: 73 percent / sec-BuLi, TMEDA / tetrahydrofuran / 1.) -78 deg C; 2.) -78 deg C to RT

With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In tetrahydrofuran;
DOI:10.1021/ja00302a024