Technology Process of <4-(1,3-dioxolan-2-yl)butyl>triphenyl phosphonium bromide
There total 1 articles about <4-(1,3-dioxolan-2-yl)butyl>triphenyl phosphonium bromide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) NaN(SiMe3)2 / 1.) THF, 0 deg C, 1 h, 2.) 20 deg C, 12 h
2: 1.) KOH / 1.) aq. EtOH, 30 deg C, 6 h, 2.) toluene, reflux, 24 h
3: 0.1 N HCl / Ambient temperature
4: toluene / pH = 8.4; buffer: LiOH, 85percent aq. H3PO4, CH3COOH, B(OH)3
5: 75 percent / Red-Al, CuBr / tetrahydrofuran; benzene / 1.) -78 -> -20 deg C, 10 min., 2.) -20 deg C, 1.5 h
With
hydrogenchloride; potassium hydroxide; sodium hexamethyldisilazane; sodium bis(2-methoxyethoxy)aluminium dihydride; copper(I) bromide;
In
tetrahydrofuran; toluene; benzene;
DOI:10.1055/s-1989-27271
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaN(SiMe3)2 / 1.) THF, 0 deg C, 1 h, 2.) 20 deg C, 12 h
2: 1.) KOH / 1.) aq. EtOH, 30 deg C, 6 h, 2.) toluene, reflux, 24 h
3: 0.1 N HCl / Ambient temperature
With
hydrogenchloride; potassium hydroxide; sodium hexamethyldisilazane;
DOI:10.1055/s-1989-27271
