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Usage

Uses

Used in Organic Synthesis:
2-(4-BROMOBUTYL)-1,3-DIOXOLANE is utilized as a reagent in organic synthesis, playing a crucial role in the formation of various organic compounds. Its unique structure allows it to participate in a range of chemical reactions, contributing to the synthesis of complex organic molecules.
Used as a Solvent:
In certain applications, 2-(4-BROMOBUTYL)-1,3-DIOXOLANE serves as a solvent, facilitating the dissolution of other substances in chemical processes. Its solvent properties can be advantageous in specific industrial applications where a suitable solvent is required for particular reactions or processes.
Used as an Intermediate in Chemical Production:
2-(4-BROMOBUTYL)-1,3-DIOXOLANE also functions as an intermediate in the production of other chemicals. Its involvement in the synthesis of various compounds makes it a valuable component in the chemical manufacturing industry, where it aids in the creation of a wide array of end products.
Used in Chemical Research:
In the field of chemical research, 2-(4-BROMOBUTYL)-1,3-DIOXOLANE is employed for studying its properties and potential applications. Researchers explore its reactivity, stability, and interactions with other compounds to gain insights into new chemical pathways and possible uses in various industries.
Used in Pharmaceutical Industry:
2-(4-BROMOBUTYL)-1,3-DIOXOLANE is used as a building block in the synthesis of pharmaceutical compounds. Its unique structure can be incorporated into drug molecules, potentially enhancing their therapeutic properties or improving their pharmacokinetic profiles.
Used in Chemical Manufacturing Industry:
In the chemical manufacturing industry, 2-(4-BROMOBUTYL)-1,3-DIOXOLANE is utilized in the production of various chemical products. Its versatility as a reagent and intermediate makes it a valuable asset in the synthesis of a wide range of chemicals used in different applications.

InChI:InChI=1/C7H13BrO2/c8-4-2-1-3-7-9-5-6-10-7/h7H,1-6H2

Upstream product

• 1191-30-6 5-bromopentanal 
• 107-21-1 ethylene glycol 
• 5454-83-1 5-bromovaleric acid methyl ester 
• 2067-33-6 5-bromopentanoic acid 
• 34626-51-2 5-bromopentan-1-ol 
• 5414-21-1 5-bromopentan-1-nitrile 

Downstream Products

• 1416352-42-5 (R)-tert-butyl 6-(1,3-dioxolan-2-yl)-2-(diphenylmethyleneamino)hexanoate 
• 1373351-47-3 (E)-ethyl 1-(4-(7-(1,3-dioxolan-2-yl)hept-2-enyloxy)phenyl)hydrazinecarboxylate 
• 1373351-46-2 (E)-2-(7-(4-iodophenoxy)hept-5-enyl)-1,3-dioxolane 

Relevant academic research and scientific papers

Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD)

The targeting of both the muscarinic and β-adrenergic pathways is a well validated therapeutic approach for the treatment of chronic obstructive pulmonary disease (COPD). In this communication we report our effort to incorporate two pharmacologies into a single chemical entity, whose characteristic must be suitable for a once daily inhaled administration. Contextually, we aimed at a locally acting therapy with limited systemic absorption to minimize side effects. Our lung-tailored design of bifunctional compounds that combine the muscarinic and β-adrenergic pharmacologies by the elaboration of the muscarinic inhibitor 7, successfully led to the potent, pharmacologically balanced muscarinic antagonist and β2 agonist (MABA) 13.

Synthesis of the C5-C30 fragment of cyclodidemniserinol trisulfate via I2-mediated deprotection and ring closure tandem reaction

The marine natural product cyclodidemniserinol trisulfate displayed moderate HIV-1 integrase inhibitory activity. Its novel structure triggered our interest to synthesize it. In our total synthesis effort, the natural product was dissected into four fragments based on the rational retrosynthetic analysis. All four fragments were successfully prepared with orthogonal protection. And the assembly of fragment A and B furnished the C5-C30 key subunit by employing the I2-mediated deprotection and intramolecular ketal formation tandem reaction in the presence of NaHCO3 in MeCN. Our work provided flexible and practical approaches to synthesize and derive the 3,5,7-trisubstituted 6,8-dioxabicyclo [3.2.1] octane based analogs to search for new structure HIV-1 integrase inhibitors.

Synthesis of a 11-deoxyprostanoid in the area of Preclavulones: (±)- 8,12-trans-(5Z-14Z)-9-oxo-prosta-5,14-dienoic acid from 2-allyl-2- cyclopenten-1-one

Following our research on the arachidonic acid metabolites and their derivatives with potential biological activity, we describe the synthesis of the (±-8,12-trans-(5Z, 14Z)-9-oxo-prosta-5,14-dienoic acid, a 11- deoxyprostanoid correlated to the class of Preclavulones, one of the unusual families of marine eicosanoids from the coral Clavularia Viridis with considerable biological interest.

Diiodosilane. 4. Direct reduction of ketals and acetals in the presence of unprotected carbonyls. A case of inverted chemoselectivity

Ketals and acetals are selectively reduced by diiodosilane to iodoalkanes in preference to ketones and aldehydes. This inversion of the normal order of reactivity of the 'protected' and 'unprotected' carbonyls allows partial reduction of polycarbonyl compounds with unusual regio- and chemoselectivity. Thus, 8,8-(ethylenedioxy)octan-2-one, 7,7-(ethylenedioxy)octanal, 3,3-(ethylenedioxy)-androstan-17-one and 3,3-(ethylenedioxy)pregnane-11,20-dione are converted to the corresponding iodo compounds.

Metabolism of phencyclidine. The role of the carbinolamine intermediate in the formation of lactam and amino acid metabolites of nitrogen heterocycles

The transformation of phencyclidine in a mouse liver microsome preparation to several oxidative metabolites was studied. With use of GLC and HPLC methods with internal standards, phencyclidine and six metabolites were quantitated and the amino acid, resulting from the α-oxidation of the piperidine ring, was produced in 10-50 times greater amounts than the other metabolites. While most piperidines and pyrrolidines produce an amino acid and a corresponding lactam, it was found that phencyclidine was not converted to the lactam.