87227-41-6

Basic information

• Product Name: 2-(4-BROMOBUTYL)-1,3-DIOXOLANE
• Synonyms: 2-(4-BROMOBUTYL)-1,3-DIOXOLANE;5-BROMOVALERALDEHYDE ETHYLENE ACETAL;Bromobutyldioxolane
• CAS NO: 87227-41-6
• Molecular Formula: C₇H₁₃BrO₂
• Molecular Weight: 209.08
• Product Categories: Dioxanes & Dioxolanes;Dioxolanes
• Mol File: 87227-41-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 237.6±15.0 °C(Predicted)
• Appearance: /
• Density: 1.38
• Refractive Index: 1.4780-1.4820
• Storage Temp.: Refrigerator
• CAS DataBase Reference: 2-(4-BROMOBUTYL)-1,3-DIOXOLANE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-BROMOBUTYL)-1,3-DIOXOLANE(87227-41-6)
• EPA Substance Registry System: 2-(4-BROMOBUTYL)-1,3-DIOXOLANE(87227-41-6)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-36-22
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 87227-41-6(Hazardous Substances Data)

Usage

General Description

2-(4-Bromobutyl)-1,3-dioxolane is a chemical compound that consists of a dioxolane ring with a bromobutyl group attached to it. 2-(4-BROMOBUTYL)-1,3-DIOXOLANE is commonly used as a reagent in organic synthesis and can also be used as a solvent or intermediate in the production of other chemicals. It has a molecular formula of C6H11BrO2 and a molecular weight of 195.06 g/mol. 2-(4-Bromobutyl)-1,3-dioxolane is flammable and should be handled with care, following proper safety protocols. It is important to consult and follow the material safety data sheet (MSDS) for this compound when handling it in a laboratory or industrial setting.

InChI:InChI=1/C7H13BrO2/c8-4-2-1-3-7-9-5-6-10-7/h7H,1-6H2

Upstream product

• 5454-83-1 5-bromovaleric acid methyl ester 
• 2067-33-6 5-bromopentanoic acid 
• 34626-51-2 5-bromopentan-1-ol 
• 5414-21-1 5-bromopentan-1-nitrile 
• 1191-30-6 5-bromopentanal 
• 107-21-1 ethylene glycol 

Downstream Products

• 313058-73-0 4-phenyl-1-(2,5-dioxacyclopentyl)butane 
• 124307-94-4 <4-(1,3-dioxolan-2-yl)butyl>triphenyl phosphonium bromide 
• 93185-14-9 5-valeraldehyde ethylene acetal 

Relevant articles and documents

Discovery of a novel class of inhaled dual pharmacology muscarinic antagonist and β2 agonist (MABA) for the treatment of chronic obstructive pulmonary disease (COPD)

The targeting of both the muscarinic and β-adrenergic pathways is a well validated therapeutic approach for the treatment of chronic obstructive pulmonary disease (COPD). In this communication we report our effort to incorporate two pharmacologies into a single chemical entity, whose characteristic must be suitable for a once daily inhaled administration. Contextually, we aimed at a locally acting therapy with limited systemic absorption to minimize side effects. Our lung-tailored design of bifunctional compounds that combine the muscarinic and β-adrenergic pharmacologies by the elaboration of the muscarinic inhibitor 7, successfully led to the potent, pharmacologically balanced muscarinic antagonist and β2 agonist (MABA) 13.

Synthesis of a 11-deoxyprostanoid in the area of Preclavulones: (±)- 8,12-trans-(5Z-14Z)-9-oxo-prosta-5,14-dienoic acid from 2-allyl-2- cyclopenten-1-one

Following our research on the arachidonic acid metabolites and their derivatives with potential biological activity, we describe the synthesis of the (±-8,12-trans-(5Z, 14Z)-9-oxo-prosta-5,14-dienoic acid, a 11- deoxyprostanoid correlated to the class of Preclavulones, one of the unusual families of marine eicosanoids from the coral Clavularia Viridis with considerable biological interest.

Metabolism of phencyclidine. The role of the carbinolamine intermediate in the formation of lactam and amino acid metabolites of nitrogen heterocycles

The transformation of phencyclidine in a mouse liver microsome preparation to several oxidative metabolites was studied. With use of GLC and HPLC methods with internal standards, phencyclidine and six metabolites were quantitated and the amino acid, resulting from the α-oxidation of the piperidine ring, was produced in 10-50 times greater amounts than the other metabolites. While most piperidines and pyrrolidines produce an amino acid and a corresponding lactam, it was found that phencyclidine was not converted to the lactam.