11-(4-chloromethyl-benzoyl)-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

Base Information

• Chemical Name: 11-(4-chloromethyl-benzoyl)-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester
• CAS No.: 321658-93-9
• Molecular Formula: C₃₃H₅₃ClN₄O₇
• Molecular Weight: 653.259
• Mol file: 321658-93-9.mol

Synonyms:11-(4-chloromethyl-benzoyl)-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

Chemical Property of 11-(4-chloromethyl-benzoyl)-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 11-(4-chloromethyl-benzoyl)-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

There total 1 articles about 11-(4-chloromethyl-benzoyl)-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

p-(chloromethyl)benzoyl chloride (876-08-4) + 1,4,8-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane (170161-27-0) → 11-(4-chloromethyl-benzoyl)-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester (321658-93-9)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1039/b004797j

Reference yield: 75.0%

5-tert-butoxycarbonyl-1,9-dithia-5,13-diazacyclohexadecane (180965-98-4) + 11-(4-chloromethyl-benzoyl)-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester (321658-93-9) → 11-[4-(13-tert-butoxycarbonyl-1,9-dithia-5,13-diaza-cyclohexadec-5-ylmethyl)-benzoyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester (321658-94-0)

Guidance literature:

With sodium carbonate; sodium iodide; In acetonitrile; for 24h; Heating;

DOI:10.1039/b004797j

Reference yield: 75.0%

4-tert-Butoxycarbonyl-1,7-dithia-4,11-diazacyclotetradecane (321658-90-6) + 11-(4-chloromethyl-benzoyl)-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester (321658-93-9) → 11-[4-(4-tert-butoxycarbonyl-1,7-dithia-4,11-diaza-cyclotetradec-11-ylmethyl)-benzoyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester (321659-05-6)

Guidance literature:

With sodium carbonate; sodium iodide; In acetonitrile; for 24h; Heating;

DOI:10.1039/b004797j

upstream raw materials:

p-(chloromethyl)benzoyl chloride

1,4,8-tris(tert-butoxycarbonyl)-1,4,8,11-tetraazacyclotetradecane

Downstream raw materials:

11-[4-(13-tert-butoxycarbonyl-1,9-dithia-5,13-diaza-cyclohexadec-5-ylmethyl)-benzoyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

11-[4-(4-tert-butoxycarbonyl-1,7-dithia-4,11-diaza-cyclotetradec-11-ylmethyl)-benzoyl]-1,4,8,11tetraaza-cyclotetradecane-1,4,8-tricarboxylic acid tri-tert-butyl ester

[4-(1,7-Dithia-4,11-diaza-cyclotetradec-11-ylmethyl)-phenyl]-(1,4,8,11-tetraaza-cyclotetradec-1-yl)-methanone

[4-(1,9-Dithia-5,13-diaza-cyclohexadec-5-ylmethyl)-phenyl]-(1,4,8,11-tetraaza-cyclotetradec-1-yl)-methanone