(Z)-(1S,5R,5(2S))-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-3-<<1-(phenylmethyl)-1H-imidazol-5-yl>methylene>cyclohexaneacetic acid ethyl ester

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Chemical Name:(Z)-(1S,5R,5(2S))-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-3-<<1-(phenylmethyl)-1H-imidazol-5-yl>methylene>cyclohexaneacetic acid ethyl ester
CAS No.:169513-57-9
Molecular Formula:C₃₃H₃₉N₃O₃
Molecular Weight:525.691
Hs Code.:

Synonyms:(Z)-(1S,5R,5(2S))-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-3-<<1-(phenylmethyl)-1H-imidazol-5-yl>methylene>cyclohexaneacetic acid ethyl ester

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Chemical Property of (Z)-(1S,5R,5(2S))-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-3-<<1-(phenylmethyl)-1H-imidazol-5-yl>methylene>cyclohexaneacetic acid ethyl ester

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Technology Process of (Z)-(1S,5R,5(2S))-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-3-<<1-(phenylmethyl)-1H-imidazol-5-yl>methylene>cyclohexaneacetic acid ethyl ester

There total 3 articles about (Z)-(1S,5R,5(2S))-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-3-<<1-(phenylmethyl)-1H-imidazol-5-yl>methylene>cyclohexaneacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 131879-99-7
(5S-5(2S))-3-oxo-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-1-cyclohexene-1-acetic acid ethyl ester

: 169513-57-9
(Z)-(1S,5R,5(2S))-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-3-<<1-(phenylmethyl)-1H-imidazol-5-yl>methylene>cyclohexaneacetic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 7.8 g / H₂ / 10percent Pd/C / ethanol / 3 h / 2585.7 Torr

2: 1.) LDA / 1.) ether, hexane, THF, from -15 to -20 deg C, 0.5 h, 2.) ether, hexane, THF, a.) -15 deg C, 15 min, b.) 0 deg C, 2.5 h

3: 1.) benzylamine / 1.) MeOH, RT, 1 h, 2.) MeOH, RT, overnight

With hydrogen; benzylamine; lithium diisopropyl amide; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00015a009

Reference yield:

: 79782-60-8
<2-<(phenylmethyl)amino>ethenyl>phosphonic acid diethyl ester

: 169513-57-9
(Z)-(1S,5R,5(2S))-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-3-<<1-(phenylmethyl)-1H-imidazol-5-yl>methylene>cyclohexaneacetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) ether, hexane, THF, from -15 to -20 deg C, 0.5 h, 2.) ether, hexane, THF, a.) -15 deg C, 15 min, b.) 0 deg C, 2.5 h

2: 1.) benzylamine / 1.) MeOH, RT, 1 h, 2.) MeOH, RT, overnight

With benzylamine; lithium diisopropyl amide;
DOI:10.1021/jm00015a009

Reference yield:

: 131880-00-7
(1S,5S,5(2S))-3-oxo-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-cyclohexaneacetic acid ethyl ester

: 169513-57-9
(Z)-(1S,5R,5(2S))-5-<<5-oxo-1-(phenylmethyl)-2-pyrrolidinyl>methyl>-3-<<1-(phenylmethyl)-1H-imidazol-5-yl>methylene>cyclohexaneacetic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) LDA / 1.) ether, hexane, THF, from -15 to -20 deg C, 0.5 h, 2.) ether, hexane, THF, a.) -15 deg C, 15 min, b.) 0 deg C, 2.5 h

2: 1.) benzylamine / 1.) MeOH, RT, 1 h, 2.) MeOH, RT, overnight

With benzylamine; lithium diisopropyl amide;
DOI:10.1021/jm00015a009