1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Base Information

• Chemical Name: 1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione
• CAS No.: 1146621-85-3
• Molecular Formula: C₂₂H₂₁N₃O₄
• Molecular Weight: 391.426

Synonyms:1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

Chemical Property of 1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

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Technology Process of 1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

There total 1 articles about 1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

[(p-methylphenyl)sulfonylmethyl]isonitrile (38622-91-2,36635-61-7) + N1,N3-dibenzyloxymethyl uracil (75499-99-9) → 1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (1146621-85-3)

Guidance literature:

With sodium hydride; In diethyl ether; dimethyl sulfoxide; for 6h;

DOI:10.1016/j.bmcl.2010.12.027

Reference yield: 73.0%

1,8-dibromooctane (4549-32-0) + 1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (1146621-85-3) → 6,6'-(octane-1,8-diyl)bis(1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione) (1269604-73-0)

Guidance literature:

DOI:10.1016/j.bmcl.2010.12.027

Reference yield: 65.0%

1,8-dibromooctane (4549-32-0) + 1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (1146621-85-3) → 1,3-bis((benzyloxy)methyl)-6-(8-bromooctyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione (1269604-72-9) + 6,6'-(octane-1,8-diyl)bis(1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione) (1269604-73-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 95 ℃; for 3h;

DOI:10.1016/j.bmcl.2010.12.027

upstream raw materials:

[(p-methylphenyl)sulfonylmethyl]isonitrile

N₁,N₃-dibenzyloxymethyl uracil

Downstream raw materials:

1,3-bis((benzyloxy)methyl)-6-(8-bromooctyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

6,6'-(octane-1,8-diyl)bis(1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione)

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