6,6'-(octane-1,8-diyl)bis(1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione)

Base Information

Chemical Name:6,6'-(octane-1,8-diyl)bis(1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione)
CAS No.:1269604-73-0
Molecular Formula:C₅₂H₅₆N₆O₈
Molecular Weight:893.052
Hs Code.:

Synonyms:6,6'-(octane-1,8-diyl)bis(1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione)

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Chemical Property of 6,6'-(octane-1,8-diyl)bis(1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione)

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Technology Process of 6,6'-(octane-1,8-diyl)bis(1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione)

There total 3 articles about 6,6'-(octane-1,8-diyl)bis(1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 4549-32-0
1,8-dibromooctane

: 1146621-85-3
1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

: 1269604-73-0
6,6'-(octane-1,8-diyl)bis(1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione)

Guidance literature:: DOI:10.1016/j.bmcl.2010.12.027

Reference yield: 65.0%

: 4549-32-0
1,8-dibromooctane

: 1146621-85-3
1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

: 1269604-72-9
1,3-bis((benzyloxy)methyl)-6-(8-bromooctyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

: 1269604-73-0
6,6'-(octane-1,8-diyl)bis(1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione)

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 95 ℃; for 3h;
DOI:10.1016/j.bmcl.2010.12.027

Reference yield:

: 75499-99-9
N₁,N₃-dibenzyloxymethyl uracil

: 1269604-72-9
1,3-bis((benzyloxy)methyl)-6-(8-bromooctyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione

: 1269604-73-0
6,6'-(octane-1,8-diyl)bis(1,3-bis((benzyloxy)methyl)-1H-pyrrolo[3,4-d]pyrimidine-2,4(3H,6H)-dione)

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydride / diethyl ether; dimethyl sulfoxide / 6 h

2: sodium hydride / N,N-dimethyl-formamide / 3 h / 95 °C

With sodium hydride; In diethyl ether; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: van Leusen pyrrole synthesis;
DOI:10.1016/j.bmcl.2010.12.027