(-)-(3R,5S)-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexanethioic acid S-ethyl ester

Base Information

Chemical Name:(-)-(3R,5S)-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexanethioic acid S-ethyl ester
CAS No.:948859-79-8
Molecular Formula:C₂₆H₃₈O₂SSi
Molecular Weight:442.738
Hs Code.:

Synonyms:(-)-(3R,5S)-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexanethioic acid S-ethyl ester

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Chemical Property of (-)-(3R,5S)-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexanethioic acid S-ethyl ester

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Technology Process of (-)-(3R,5S)-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexanethioic acid S-ethyl ester

There total 8 articles about (-)-(3R,5S)-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexanethioic acid S-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: C₂₅H₃₄O₂SSi

: 75-16-1
methylmagnesium bromide

: 948859-79-8
(-)-(3R,5S)-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexanethioic acid S-ethyl ester

Guidance literature:: With (R)-1-[(S)-2-(diphenylphosphino)ferrocenyl]ethyldicyclohexylphosphine ethanol; copper(I) bromide; at -78 ℃; optical yield given as %de; diastereoselective reaction;
DOI:10.1039/c1ob06700a

Reference yield: 90.0%

: 948859-73-2
(-)-(E)-(S)-6-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hex-2-enethioic acid S-ethyl ester

: 75-16-1
methylmagnesium bromide

: 948859-79-8
(-)-(3R,5S)-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexanethioic acid S-ethyl ester

Guidance literature:: methylmagnesium bromide; With (S,R(Fe))-Josiphos/CuBr; In diethyl ether; tert-butyl methyl ether; at -75 ℃; for 0.166667h; Inert atmosphere;

(-)-(E)-(S)-6-(tert-butyl-diphenyl-silanyloxy)-5-methyl-hex-2-enethioic acid S-ethyl ester; In diethyl ether; tert-butyl methyl ether; at -75 ℃; optical yield given as %de; diastereoselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.200901120

Reference yield:

: 948859-72-1
(-)-(S)-4-(tert-butyl-diphenyl-silanyloxy)-3-methyl-thiobutyric acid S-ethyl ester

: 948859-79-8
(-)-(3R,5S)-6-(tert-butyl-diphenyl-silanyloxy)-3,5-dimethyl-hexanethioic acid S-ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: diisobutylaluminium hydride / dichloromethane / -65 °C

2: n-butyllithium

3: 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine; copper(I) bromide / -78 °C

With 2-(diphenylphosphino)ferrocenylethyldicyclohexylphosphine; n-butyllithium; diisobutylaluminium hydride; copper(I) bromide; In dichloromethane;
DOI:10.1039/c1ob06700a