C₆₆H₉₃N₁₁O₁₈

Base Information

• Chemical Name: C₆₆H₉₃N₁₁O₁₈
• CAS No.: 1632161-64-8
• Molecular Formula: C₆₆H₉₃N₁₁O₁₈
• Molecular Weight: 1328.53
• Mol file: 1632161-64-8.mol

Synonyms:C₆₆H₉₃N₁₁O₁₈

Chemical Property of C₆₆H₉₃N₁₁O₁₈

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of C₆₆H₉₃N₁₁O₁₈

There total 5 articles about C₆₆H₉₃N₁₁O₁₈ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]5-amino-6-oxohexyl}carbamic acid tert-butyl ester (1258973-74-8) + 4-[[6-[(2,2-dimethyl-1,3-dioxolan-4-yl)methylamino]-7-(4-hydroxy-4-oxo-butoxy)-2-naphtyl]oxy]butanoic acid (1632161-77-3) → C66H93N11O18 (1632161-64-8)

Guidance literature:

With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 48h; Inert atmosphere;

DOI:10.1039/c4md00032c

Reference yield:

benzyl 4-[[7-(4-benzyloxy-4-oxo-butoxy)-6-[(2,2-dimethyl-1,3-dioxolan-4-yl)methylamino]-2-naphthyl]oxy]butanoate (1632161-76-2) → C66H93N11O18 (1632161-64-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogen; palladium on carbon / methanol; ethyl acetate / 24 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With palladium on carbon; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1039/c4md00032c

Reference yield:

benzyl 4-[[7-(4-benzyloxy-4-oxo-butoxy)-6-bromo-2-naphthyl]oxy]butanoate (1632161-74-0) → C66H93N11O18 (1632161-64-8)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate; palladium diacetate; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene / 1,4-dioxane / 15 h / 110 °C / Schlenk technique; Inert atmosphere

2: hydrogen; palladium on carbon / methanol; ethyl acetate / 24 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; benzotriazol-1-ol / N,N-dimethyl-formamide / 48 h / 20 °C / Inert atmosphere

With palladium on carbon; hydrogen; palladium diacetate; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphos4,5-bis(diphenylphosphino)-9,9-dimethylxanthenephino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; ethyl acetate; N,N-dimethyl-formamide; 1: |Buchwald-Hartwig Coupling;

DOI:10.1039/c4md00032c

upstream raw materials:

3-bromonaphthalene-2,7-diol

benzyl 4-[[7-(4-benzyloxy-4-oxo-butoxy)-6-bromo-2-naphthyl]oxy]butanoate

benzyl 4-[[7-(4-benzyloxy-4-oxo-butoxy)-6-[(2,2-dimethyl-1,3-dioxolan-4-yl)methylamino]-2-naphthyl]oxy]butanoate

{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]5-amino-6-oxohexyl}carbamic acid tert-butyl ester

Downstream raw materials:

C₆₃H₈₉N₁₁O₁₈