{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]5-amino-6-oxohexyl}carbamic acid tert-butyl ester

Base Information

• Chemical Name: {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]5-amino-6-oxohexyl}carbamic acid tert-butyl ester
• CAS No.: 1258973-74-8
• Molecular Formula: C₂₁H₃₃N₅O₆
• Molecular Weight: 451.523
• Mol file: 1258973-74-8.mol

Synonyms:{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]5-amino-6-oxohexyl}carbamic acid tert-butyl ester

Chemical Property of {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]5-amino-6-oxohexyl}carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]5-amino-6-oxohexyl}carbamic acid tert-butyl ester

There total 3 articles about {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]5-amino-6-oxohexyl}carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-benzyloxycarbonylamino-6-oxohexyl}carbamic acid tert-butyl ester (1258973-70-4) → {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]5-amino-6-oxohexyl}carbamic acid tert-butyl ester (1258973-74-8)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 12h;

DOI:10.1002/cmdc.201000308

Reference yield:

N-(3-hydrazinocarbonyl-4-methoxyphenyl)acetamide (131308-91-3) → {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]5-amino-6-oxohexyl}carbamic acid tert-butyl ester (1258973-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201000308

Reference yield:

N-Boc-N-Z-K-OH (34279-80-6) → {6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]5-amino-6-oxohexyl}carbamic acid tert-butyl ester (1258973-74-8)

Guidance literature:

Multi-step reaction with 2 steps

1: benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol / 12 h / 20 °C

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;

DOI:10.1002/cmdc.201000308

upstream raw materials:

N-(3-hydrazinocarbonyl-4-methoxyphenyl)acetamide

{6-[N'-(5-acetylamino-2-methoxybenzoyl)hydrazino]-5-benzyloxycarbonylamino-6-oxohexyl}carbamic acid tert-butyl ester

N-Boc-N-Z-K-OH

Downstream raw materials:

C₂HF₃O₂*C₅₁H₇₄N₈O₁₂

C₅₆H₈₂N₈O₁₄

C₆₀H₈₂N₁₀O₁₆

C₆₆H₉₃N₁₁O₁₈