{(S)-1-[(S)-1-((S)-1-Hydroxymethyl-3-methylsulfanyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester

Base Information

• Chemical Name: {(S)-1-[(S)-1-((S)-1-Hydroxymethyl-3-methylsulfanyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester
• CAS No.: 199005-49-7
• Molecular Formula: C₂₈H₃₉N₃O₅S
• Molecular Weight: 529.701

Synonyms:{(S)-1-[(S)-1-((S)-1-Hydroxymethyl-3-methylsulfanyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester

Chemical Property of {(S)-1-[(S)-1-((S)-1-Hydroxymethyl-3-methylsulfanyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester

Chemical Property:

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Technology Process of {(S)-1-[(S)-1-((S)-1-Hydroxymethyl-3-methylsulfanyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester

There total 2 articles about {(S)-1-[(S)-1-((S)-1-Hydroxymethyl-3-methylsulfanyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyloxycarbonyl-L-leucyl-L-phenylalanine (6401-63-4) → {(S)-1-[(S)-1-((S)-1-Hydroxymethyl-3-methylsulfanyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester (199005-49-7)

Guidance literature:

Multi-step reaction with 2 steps

1: DCC / CH₂Cl₂; dimethylformamide / 3 h / Ambient temperature

2: dimethylformamide / 12 h / Ambient temperature

With dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm980071x

Reference yield:

(S)-methioninol (2899-37-8) + (S)-2-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-3-phenyl-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester → {(S)-1-[(S)-1-((S)-1-Hydroxymethyl-3-methylsulfanyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester (199005-49-7)

Guidance literature:

In N,N-dimethyl-formamide; for 12h; Yield given; Ambient temperature;

DOI:10.1021/jm980071x

Reference yield: 90.0%

{(S)-1-[(S)-1-((S)-1-Hydroxymethyl-3-methylsulfanyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester (199005-49-7) → {(S)-1-[(S)-1-((S)-1-Hydroxymethyl-3-methanesulfinyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester (199005-50-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 1h; Ambient temperature;

DOI:10.1021/jm980071x

upstream raw materials:

(S)-methioninol

N-benzyloxycarbonyl-L-leucyl-L-phenylalanine

Downstream raw materials:

{(S)-1-[(S)-1-((S)-1-Hydroxymethyl-3-methanesulfinyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester

{(S)-1-[(S)-1-((S)-1-Formyl-3-methanesulfinyl-propylcarbamoyl)-2-phenyl-ethylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester

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