N-[6-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinyl}-4-methyl-1H-imidazol-5-yl)-3-pyridinyl]acetamide

Base Information

Chemical Name:N-[6-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinyl}-4-methyl-1H-imidazol-5-yl)-3-pyridinyl]acetamide
CAS No.:1445864-93-6
Molecular Formula:C₂₆H₂₂ClN₉O₂
Molecular Weight:527.973
Hs Code.:

Synonyms:N-[6-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinyl}-4-methyl-1H-imidazol-5-yl)-3-pyridinyl]acetamide

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Chemical Property of N-[6-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinyl}-4-methyl-1H-imidazol-5-yl)-3-pyridinyl]acetamide

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Technology Process of N-[6-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinyl}-4-methyl-1H-imidazol-5-yl)-3-pyridinyl]acetamide

There total 13 articles about N-[6-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinyl}-4-methyl-1H-imidazol-5-yl)-3-pyridinyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₀ClN₇O₄

: 64-19-7,77671-22-8
acetic acid

: 1445864-92-5
(3S)-3-[5-(5-amino-2-pyridinyl)-4-methyl-1H-imidazol-2-yl]-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-2,3-dihydro-5(1H)-indolizinone

: 1445864-93-6
N-[6-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinyl}-4-methyl-1H-imidazol-5-yl)-3-pyridinyl]acetamide

Guidance literature:: With ammonium acetate; In toluene; for 2h; Reflux;

Reference yield:

: 1445865-59-7
(3S)-7-(2-amino-5-chlorophenyl)-5-oxo-1,2,3,5-tetrahydroindolizine-3-carboxylic acid

: 1445864-93-6
N-[6-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinyl}-4-methyl-1H-imidazol-5-yl)-3-pyridinyl]acetamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetic acid / 0.5 h

1.2: 20 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 2 h / 20 °C

3.1: ammonium acetate / toluene / 2 h / Reflux

With ammonium acetate; potassium carbonate; acetic acid; In N,N-dimethyl-formamide; toluene;

Reference yield:

: 7149-65-7
ethyl (S)-pyroglutamate

: 1445864-93-6
N-[6-(2-{(3S)-7-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]-5-oxo-1,2,3,5-tetrahydro-3-indolizinyl}-4-methyl-1H-imidazol-5-yl)-3-pyridinyl]acetamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: dichloromethane / 3 h / 20 °C

2.1: triethylamine / 3 h / 120 °C

3.1: sodium hydroxide / 20 °C

4.1: hydrogenchloride; water / 20 h / 140 °C

5.1: sulfuric acid / 4 h / 100 °C

6.1: triethylamine / N,N-dimethyl-formamide / 1 h / 20 °C

7.1: cesium fluoride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 0.5 h / 105 °C / Inert atmosphere

8.1: sodium hydroxide; methanol / 4 h / 20 °C

9.1: acetic acid / 0.5 h

9.2: 20 °C

10.1: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 20 °C

10.2: 2 h / 20 °C

11.1: ammonium acetate / toluene / 2 h / Reflux

With hydrogenchloride; methanol; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sulfuric acid; ammonium acetate; water; potassium carbonate; acetic acid; triethylamine; cesium fluoride; sodium hydroxide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; toluene;