3',3''-difluoro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)diphenyl ketone

Base Information

Chemical Name:3',3''-difluoro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)diphenyl ketone
CAS No.:252934-53-5
Molecular Formula:C₁₉H₁₆F₂O₇
Molecular Weight:394.329
Hs Code.:

Synonyms:3',3''-difluoro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)diphenyl ketone

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Chemical Property of 3',3''-difluoro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)diphenyl ketone

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Technology Process of 3',3''-difluoro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)diphenyl ketone

There total 3 articles about 3',3''-difluoro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)diphenyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 252934-52-4
[3',3''-difluoro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)diphenyl]methane

: 252934-53-5
3',3''-difluoro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)diphenyl ketone

Guidance literature:: With chromium(VI) oxide; acetic anhydride; at 20 ℃; for 20h;
DOI:10.1021/jm990343b

Reference yield:

: 341-27-5
3-fluorosalicylic acid

: 252934-53-5
3',3''-difluoro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)diphenyl ketone

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. H₂SO₄ / methanol / 1 h / 0 °C

1.2: 95 percent / methanol; H₂O / 5 h / 0 °C

2.1: 79 percent / K₂CO₃ / acetone / 20 h / Heating

3.1: 81 percent / CrO₃; Ac₂O / 20 h / 20 °C

With chromium(VI) oxide; sulfuric acid; acetic anhydride; potassium carbonate; In methanol; acetone; 1.1: sulfonation / 1.2: Condensation / 2.1: Esterification / 3.1: Oxidation;
DOI:10.1021/jm990343b

Reference yield:

: 252934-51-3
(3',3''-dicarboxy-5,5'-difluoro-4',4''-dihydroxydiphenyl)methane

: 252934-53-5
3',3''-difluoro-4',4''-dimethoxy-5',5''-bis(methoxycarbonyl)diphenyl ketone

Guidance literature:: Multi-step reaction with 2 steps

1: 79 percent / K₂CO₃ / acetone / 20 h / Heating

2: 81 percent / CrO₃; Ac₂O / 20 h / 20 °C

With chromium(VI) oxide; acetic anhydride; potassium carbonate; In acetone; 1: Esterification / 2: Oxidation;
DOI:10.1021/jm990343b